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Human BRCA pathogenic variants were originated during recent human history

BRCA1 and BRCA2 (BRCA) play essential roles in maintaining genome stability. BRCA germline pathogenic variants increase cancer risk. However, the evolutionary origin of human BRCA pathogenic variants remains largely elusive. We tested the 2,972 human BRCA1 and 3,652 human BRCA2 pathogenic variants f...

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Detalles Bibliográficos
Autores principales:	Li, Jiaheng, Zhao, Bojin, Huang, Teng, Qin, Zixin, Wang, San Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860097/ https://www.ncbi.nlm.nih.gov/pubmed/35165121 http://dx.doi.org/10.26508/lsa.202101263

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