Intravenous administration of mesenchymal stromal cells leads to a dose-dependent coagulopathy and is unable to attenuate acute traumatic coagulopathy in rats

BACKGROUND: Mesenchymal stromal cells (MSCs) express surface tissue factor (TF), which may affect hemostasis and detract from therapeutic outcomes of MSCs if administered intravenously. In this study, we determine a safe dose of MSCs for intravenous (IV) administration and further demonstrate the im...

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Detalles Bibliográficos
Autores principales: Wu, Xiaowu, Darlington, Daniel N., Christy, Barbara A., Liu, Bin, Keesee, Jeffrey D., Salgado, Christi L., Bynum, James A., Cap, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Independent Submissions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860226/
https://www.ncbi.nlm.nih.gov/pubmed/34797814
http://dx.doi.org/10.1097/TA.0000000000003476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860226/
https://www.ncbi.nlm.nih.gov/pubmed/34797814
http://dx.doi.org/10.1097/TA.0000000000003476

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