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Intravenous administration of mesenchymal stromal cells leads to a dose-dependent coagulopathy and is unable to attenuate acute traumatic coagulopathy in rats

BACKGROUND: Mesenchymal stromal cells (MSCs) express surface tissue factor (TF), which may affect hemostasis and detract from therapeutic outcomes of MSCs if administered intravenously. In this study, we determine a safe dose of MSCs for intravenous (IV) administration and further demonstrate the im...

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Detalles Bibliográficos
Autores principales:	Wu, Xiaowu, Darlington, Daniel N., Christy, Barbara A., Liu, Bin, Keesee, Jeffrey D., Salgado, Christi L., Bynum, James A., Cap, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Independent Submissions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860226/ https://www.ncbi.nlm.nih.gov/pubmed/34797814 http://dx.doi.org/10.1097/TA.0000000000003476

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