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Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata
Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persiste...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860347/ https://www.ncbi.nlm.nih.gov/pubmed/35210753 http://dx.doi.org/10.2147/DDDT.S334727 |
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author | Ramírez-Marín, Hassiel Aurelio Tosti, Antonella |
author_facet | Ramírez-Marín, Hassiel Aurelio Tosti, Antonella |
author_sort | Ramírez-Marín, Hassiel Aurelio |
collection | PubMed |
description | Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persistent illness. There is an ongoing need for a treatment that demonstrates a good clinical response with a benefit-risk ratio that is suitable for long-term use, especially for patients with chronic, extensive disease. Several clinical trials and case studies that have assessed Janus kinase inhibitors have had encouraging results. Ritlecitinib, a selective JAK3/TEC kinase inhibitor has been demonstrated to inhibit the action of signaling molecules and immune cells that are responsible for hair loss in people with alopecia areata. Furthermore, several clinical trials are investigating the utility of ritlecitinib in patients with vitiligo, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Advantages of using ritlecitinib when compared with other non-selective JAK inhibitors include avoiding JAK1/JAK2 inhibition’s clinical repercussions, which include pharmacodynamic effects such as increased cholesterol and liver enzymes, and those related to JAK2 inhibition (thrombocytopenia, anemia). Treatment with Ritlecitinib 50 mg and 30 mg daily for 24 weeks has been shown to induce hair regrowth with a significant proportion of patients reaching SALT 20 (≤20% scalp hair loss) after six months of therapy compared to placebo. Additional research is needed for long-term effects. |
format | Online Article Text |
id | pubmed-8860347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-88603472022-02-23 Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata Ramírez-Marín, Hassiel Aurelio Tosti, Antonella Drug Des Devel Ther Review Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persistent illness. There is an ongoing need for a treatment that demonstrates a good clinical response with a benefit-risk ratio that is suitable for long-term use, especially for patients with chronic, extensive disease. Several clinical trials and case studies that have assessed Janus kinase inhibitors have had encouraging results. Ritlecitinib, a selective JAK3/TEC kinase inhibitor has been demonstrated to inhibit the action of signaling molecules and immune cells that are responsible for hair loss in people with alopecia areata. Furthermore, several clinical trials are investigating the utility of ritlecitinib in patients with vitiligo, rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. Advantages of using ritlecitinib when compared with other non-selective JAK inhibitors include avoiding JAK1/JAK2 inhibition’s clinical repercussions, which include pharmacodynamic effects such as increased cholesterol and liver enzymes, and those related to JAK2 inhibition (thrombocytopenia, anemia). Treatment with Ritlecitinib 50 mg and 30 mg daily for 24 weeks has been shown to induce hair regrowth with a significant proportion of patients reaching SALT 20 (≤20% scalp hair loss) after six months of therapy compared to placebo. Additional research is needed for long-term effects. Dove 2022-02-17 /pmc/articles/PMC8860347/ /pubmed/35210753 http://dx.doi.org/10.2147/DDDT.S334727 Text en © 2022 Ramírez-Marín and Tosti. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Ramírez-Marín, Hassiel Aurelio Tosti, Antonella Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title | Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title_full | Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title_fullStr | Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title_full_unstemmed | Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title_short | Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata |
title_sort | evaluating the therapeutic potential of ritlecitinib for the treatment of alopecia areata |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860347/ https://www.ncbi.nlm.nih.gov/pubmed/35210753 http://dx.doi.org/10.2147/DDDT.S334727 |
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