P2Y1 purinergic receptor identified as a diabetes target in a small-molecule screen to reverse circadian β-cell failure

The mammalian circadian clock drives daily oscillations in physiology and behavior through an autoregulatory transcription feedback loop present in central and peripheral cells. Ablation of the core clock within the endocrine pancreas of adult animals impairs the transcription and splicing of genes...

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Detalles Bibliográficos
Autores principales: Marcheva, Biliana, Weidemann, Benjamin J, Taguchi, Akihiko, Perelis, Mark, Ramsey, Kathryn Moynihan, Newman, Marsha V, Kobayashi, Yumiko, Omura, Chiaki, Manning Fox, Jocelyn E, Lin, Haopeng, Macdonald, Patrick E, Bass, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860442/
https://www.ncbi.nlm.nih.gov/pubmed/35188462
http://dx.doi.org/10.7554/eLife.75132

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