Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import of pyruvate into mitochondria occuring exclusively via the mitochondrial pyruvate carrier (MPC). To investigate whether def...

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Detalles Bibliográficos
Autores principales: De La Rossa, Andres, Laporte, Marine H, Astori, Simone, Marissal, Thomas, Montessuit, Sylvie, Sheshadri, Preethi, Ramos-Fernández, Eva, Mendez, Pablo, Khani, Abbas, Quairiaux, Charles, Taylor, Eric B, Rutter, Jared, Nunes, José Manuel, Carleton, Alan, Duchen, Michael R, Sandi, Carmen, Martinou, Jean-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860443/
https://www.ncbi.nlm.nih.gov/pubmed/35188099
http://dx.doi.org/10.7554/eLife.72595

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