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TNF-α Antagonizes the Effect of Leptin on Insulin Secretion through FOXO1-Dependent Transcriptional Suppression of LepRb in INS-1 Cells

Proinflammatory cytokines play a causal role in the development of hyperinsulinemia and T2MD. FOXO1, a transcription factor which is known to enhance proinflammation, was recently shown to be involved in obesity-induced β cell dysfunction. However, molecular mechanisms for the association remained e...

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Detalles Bibliográficos
Autores principales:	Zhang, Yang, Jin, Weidong, Zhang, Dongyun, Lin, Changhai, He, Haiyan, Xie, Fengxin, Gan, Lixia, Fu, Weiling, Wu, Lixiang, Wu, Yongzhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860543/ https://www.ncbi.nlm.nih.gov/pubmed/35198097 http://dx.doi.org/10.1155/2022/9142798

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