Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5-Aminouracil: A Different Binding Mode from the Anticancer Drug 5-Fluorouracil

Dihydropyrimidinase (DHPase) is a key enzyme for pyrimidine degradation. DHPase contains a binuclear metal center in which two Zn ions are bridged by a posttranslationally carbamylated lysine. DHPase catalyzes the hydrolysis of dihydrouracil to N-carbamoyl-β-alanine. Whether 5-aminouracil (5-AU), a...

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Detalles Bibliográficos
Autores principales: Lin, En-Shyh, Luo, Ren-Hong, Yang, Ya-Ching, Huang, Cheng-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860565/
https://www.ncbi.nlm.nih.gov/pubmed/35198016
http://dx.doi.org/10.1155/2022/1817745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860565/
https://www.ncbi.nlm.nih.gov/pubmed/35198016
http://dx.doi.org/10.1155/2022/1817745

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