TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination

Expression of the E3 ligase TRIM21 is increased in a broad spectrum of cancers; however, the functionally relevant molecular pathway targeted by TRIM21 overexpression remains largely unknown. Here, we show that TRIM21 directly interacts with and ubiquitinates CLASPIN, a mediator for ATR-dependent CH...

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Detalles Bibliográficos
Autores principales: Zhu, Xuefei, Xue, Jingwei, Jiang, Xing, Gong, Yamin, Gao, Congwen, Cao, Ting, Li, Qian, Bai, Lulu, Li, Yuwei, Xu, Gaixia, Peng, Bin, Xu, Xingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860585/
https://www.ncbi.nlm.nih.gov/pubmed/35048968
http://dx.doi.org/10.1093/nar/gkac011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860585/
https://www.ncbi.nlm.nih.gov/pubmed/35048968
http://dx.doi.org/10.1093/nar/gkac011

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