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Selection and identification of an RNA aptamer that specifically binds the HIV-1 capsid lattice and inhibits viral replication

The HIV-1 capsid core participates in several replication processes. The mature capsid core is a lattice composed of capsid (CA) monomers thought to assemble first into CA dimers, then into ∼250 CA hexamers and 12 CA pentamers. CA assembly requires conformational flexibility of each unit, resulting...

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Detalles Bibliográficos
Autores principales:	Gruenke, Paige R, Aneja, Rachna, Welbourn, Sarah, Ukah, Obiaara B, Sarafianos, Stefan G, Burke, Donald H, Lange, Margaret J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860611/ https://www.ncbi.nlm.nih.gov/pubmed/35018437 http://dx.doi.org/10.1093/nar/gkab1293

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