The role of tissue maturity and mechanical state in controlling cell extrusion

Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whol...

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Detalles Bibliográficos
Autores principales: Zulueta-Coarasa, Teresa, Rosenblatt, Jody
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860846/
https://www.ncbi.nlm.nih.gov/pubmed/34560388
http://dx.doi.org/10.1016/j.gde.2021.09.003
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author Zulueta-Coarasa, Teresa
Rosenblatt, Jody
author_facet Zulueta-Coarasa, Teresa
Rosenblatt, Jody
author_sort Zulueta-Coarasa, Teresa
collection PubMed
description Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissue-mechanics, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell–cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease.
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spelling pubmed-88608462022-02-22 The role of tissue maturity and mechanical state in controlling cell extrusion Zulueta-Coarasa, Teresa Rosenblatt, Jody Curr Opin Genet Dev Article Epithelia remove dying or excess cells by extrusion, a process that seamlessly squeezes cells out of the layer without disrupting their barrier function. New studies shed light into the intricate relationship between extrusion, tissue mechanics, and development. They emphasize the importance of whole tissue-mechanics, rather than single cell-mechanics in controlling extrusion. Tissue compaction, stiffness, and cell–cell adhesion can impact the efficiency of cell extrusion and mechanisms that drive it, to adapt to different conditions during development or disease. 2022-02 2021-09-21 /pmc/articles/PMC8860846/ /pubmed/34560388 http://dx.doi.org/10.1016/j.gde.2021.09.003 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Zulueta-Coarasa, Teresa
Rosenblatt, Jody
The role of tissue maturity and mechanical state in controlling cell extrusion
title The role of tissue maturity and mechanical state in controlling cell extrusion
title_full The role of tissue maturity and mechanical state in controlling cell extrusion
title_fullStr The role of tissue maturity and mechanical state in controlling cell extrusion
title_full_unstemmed The role of tissue maturity and mechanical state in controlling cell extrusion
title_short The role of tissue maturity and mechanical state in controlling cell extrusion
title_sort role of tissue maturity and mechanical state in controlling cell extrusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860846/
https://www.ncbi.nlm.nih.gov/pubmed/34560388
http://dx.doi.org/10.1016/j.gde.2021.09.003
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