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Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review
Gastric cancer is considered to be a type of gastrointestinal tumor and is mostly accompanied by Helicobacter pylori (HP) infection at the early stage. Hence, the long-term colonization of the gastric mucosa by HP as a causative factor for gastrointestinal diseases cannot be ignored. The virulence f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860906/ https://www.ncbi.nlm.nih.gov/pubmed/35211104 http://dx.doi.org/10.3389/fmicb.2022.811258 |
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author | Han, Lu Shu, Xu Wang, Jian |
author_facet | Han, Lu Shu, Xu Wang, Jian |
author_sort | Han, Lu |
collection | PubMed |
description | Gastric cancer is considered to be a type of gastrointestinal tumor and is mostly accompanied by Helicobacter pylori (HP) infection at the early stage. Hence, the long-term colonization of the gastric mucosa by HP as a causative factor for gastrointestinal diseases cannot be ignored. The virulence factors secreted by the bacterium activate the signaling pathway of oxidative stress and mediate chronic inflammatory response in the host cells. The virulence factors also thwart the antibacterial effect of neutrophils. Subsequently, DNA methylation is induced, which causes continuous cell proliferation and evolution toward low-grade-differentiated gastric cells. This process provides the pathological basis for the occurrence of progressive gastric cancer. Therefore, this review aims to summarize the oxidative stress response triggered by HP in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer. |
format | Online Article Text |
id | pubmed-8860906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88609062022-02-23 Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review Han, Lu Shu, Xu Wang, Jian Front Microbiol Microbiology Gastric cancer is considered to be a type of gastrointestinal tumor and is mostly accompanied by Helicobacter pylori (HP) infection at the early stage. Hence, the long-term colonization of the gastric mucosa by HP as a causative factor for gastrointestinal diseases cannot be ignored. The virulence factors secreted by the bacterium activate the signaling pathway of oxidative stress and mediate chronic inflammatory response in the host cells. The virulence factors also thwart the antibacterial effect of neutrophils. Subsequently, DNA methylation is induced, which causes continuous cell proliferation and evolution toward low-grade-differentiated gastric cells. This process provides the pathological basis for the occurrence of progressive gastric cancer. Therefore, this review aims to summarize the oxidative stress response triggered by HP in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer. Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8860906/ /pubmed/35211104 http://dx.doi.org/10.3389/fmicb.2022.811258 Text en Copyright © 2022 Han, Shu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Han, Lu Shu, Xu Wang, Jian Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title | Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title_full | Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title_fullStr | Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title_full_unstemmed | Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title_short | Helicobacter pylori-Mediated Oxidative Stress and Gastric Diseases: A Review |
title_sort | helicobacter pylori-mediated oxidative stress and gastric diseases: a review |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860906/ https://www.ncbi.nlm.nih.gov/pubmed/35211104 http://dx.doi.org/10.3389/fmicb.2022.811258 |
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