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Rad52 mediates class-switch DNA recombination to IgD
In B cells, IgD is expressed together with IgM through alternative splicing of primary V(H)DJ(H)-Cμ-s-m-Cδ-s-m RNAs, and also through IgD class switch DNA recombination (CSR) via double-strand DNA breaks (DSB) and synapse of Sμ with σδ. How such DSBs are resolved is still unknown, despite our previo...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861003/ https://www.ncbi.nlm.nih.gov/pubmed/35190531 http://dx.doi.org/10.1038/s41467-022-28576-2 |