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Sepsis downregulates aortic Notch signaling to produce vascular hyporeactivity in mice

Inhibition of Notch signaling in macrophages is known to reduce inflammation, however, its role in regulating vascular hyporeactivity in sepsis is unknown. Thus we aimed to evaluate the effect of sepsis on vascular Notch signaling. Polymicrobial sepsis was induced by caecal ligation and puncture (CL...

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Detalles Bibliográficos
Autores principales:	Singh, Vandana, Akash, Raut, Chaudhary, Gaurav, Singh, Rajneesh, Choudhury, Soumen, Shukla, Amit, Prabhu, Shyama N., Gangwar, Neeraj, Garg, Satish K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861011/ https://www.ncbi.nlm.nih.gov/pubmed/35190630 http://dx.doi.org/10.1038/s41598-022-06949-3

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