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PLP2-derived peptide Rb4 triggers PARP-1-mediated necrotic death in murine melanoma cells

Malignant melanoma is the main cause of death in patients with skin cancer. Overexpression of Proteolipid protein 2 (PLP2) increased tumor metastasis and the knockdown of PLP2 inhibited the growth and metastasis of melanoma cells. In the present work, we studied the antitumor activity of peptide Rb4...

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Detalles Bibliográficos
Autores principales:	Maia, Vera S. C., Berzaghi, Rodrigo, Arruda, Denise C., Machado, Fabrício C., Loureiro, Leticia L., Melo, Pollyana M. S., Morais, Alice S., Budu, Alexandre, Travassos, Luiz R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861012/ https://www.ncbi.nlm.nih.gov/pubmed/35190586 http://dx.doi.org/10.1038/s41598-022-06429-8

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