Design, synthesis and evaluation of novel 2-oxoindoline-based acetohydrazides as antitumor agents

In our search for novel small molecules activating procaspase-3, we have designed and synthesized two series of novel (E)-N'-arylidene-2-(2-oxoindolin-1-yl)acetohydrazides (4) and (Z)-2-(5-substituted-2-oxoindolin-1-yl)-N'-(2-oxoindolin-3-ylidene)acetohydrazides (5). Cytotoxic evaluation r...

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Detalles Bibliográficos
Autores principales: Dung, Do T. M., Park, Eun J., Anh, Duong T., Phan, Dung T. P., Na, Ik H., Kwon, Joo H., Kang, Jong S., Tung, Truong T., Han, Sang-Bae, Nam, Nguyen-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861050/
https://www.ncbi.nlm.nih.gov/pubmed/35190616
http://dx.doi.org/10.1038/s41598-022-06887-0

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