Can two wrongs make a right? F508del-CFTR ion channel rescue by second-site mutations in its transmembrane domains

Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most common cause of cystic fibrosis. The F508 residue is located on nucleotide-binding domain 1 (NBD1) in contact with the cytosolic extensions of the transmembrane helices...

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Detalles Bibliográficos
Autores principales: Prins, Stella, Corradi, Valentina, Sheppard, David N., Tieleman, D. Peter, Vergani, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861112/
https://www.ncbi.nlm.nih.gov/pubmed/35065958
http://dx.doi.org/10.1016/j.jbc.2022.101615

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