Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response

Both the DNA damage response (DDR) and the mitotic checkpoint are critical for the maintenance of genomic stability. Among proteins involved in these processes, the ataxia–telangiectasia mutated (ATM) kinase is required for both activation of the DDR and the spindle assembly checkpoint (SAC). In mit...

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Detalles Bibliográficos
Autores principales: Xiao, Mingming, Zhang, Siyue, Liu, Zhuang, Mo, Yaqi, Wang, Han, Zhao, Xu, Yang, Xue, Boohaker, Rebecca J., Chen, Yang, Han, Yamei, Liu, Hong, Xu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861116/
https://www.ncbi.nlm.nih.gov/pubmed/35085551
http://dx.doi.org/10.1016/j.jbc.2022.101632

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