Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic trait that can cause hemolytic anemia. To date, over 150 nonsynonymous mutations have been identified in G6PD, with pathogenic mutations clustering near the dimer and/or tetramer interface and the allosteric NADP(+)-binding site. Recen...

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Detalles Bibliográficos
Autores principales: Garcia, Adriana Ann, Mathews, Irimpan I., Horikoshi, Naoki, Matsui, Tsutomu, Kaur, Manat, Wakatsuki, Soichi, Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861134/
https://www.ncbi.nlm.nih.gov/pubmed/35065072
http://dx.doi.org/10.1016/j.jbc.2022.101610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861134/
https://www.ncbi.nlm.nih.gov/pubmed/35065072
http://dx.doi.org/10.1016/j.jbc.2022.101610

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