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Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state

The conserved ATPase p97 (Cdc48 in yeast) and adaptors mediate diverse cellular processes through unfolding polyubiquitinated proteins and extracting them from macromolecular assemblies and membranes for disaggregation and degradation. The tandem ATPase domains (D1 and D2) of the p97/Cdc48 hexamer f...

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Detalles Bibliográficos
Autores principales:	Gao, Haishan, Li, Faxiang, Ji, Zhejian, Shi, Zhubing, Li, Yang, Yu, Hongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861141/ https://www.ncbi.nlm.nih.gov/pubmed/35190543 http://dx.doi.org/10.1038/s41421-022-00379-1

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