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How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication

High-dose alcohol intoxication is commonly associated with impaired inhibition, but the boundary conditions, as well as associated neurocognitive/neuroanatomical changes have remained rather unclear. This study was motivated by the counterintuitive finding that high-dose alcohol intoxication comprom...

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Autores principales: Stock, Ann-Kathrin, Yu, Shijing, Ghin, Filippo, Beste, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861183/
https://www.ncbi.nlm.nih.gov/pubmed/35190563
http://dx.doi.org/10.1038/s41598-022-06517-9
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author Stock, Ann-Kathrin
Yu, Shijing
Ghin, Filippo
Beste, Christian
author_facet Stock, Ann-Kathrin
Yu, Shijing
Ghin, Filippo
Beste, Christian
author_sort Stock, Ann-Kathrin
collection PubMed
description High-dose alcohol intoxication is commonly associated with impaired inhibition, but the boundary conditions, as well as associated neurocognitive/neuroanatomical changes have remained rather unclear. This study was motivated by the counterintuitive finding that high-dose alcohol intoxication compromises response inhibition performance when working memory demands were low, but not when they were high. To investigate whether this is more likely to be caused by deficits in cognitive control processes or in attentional processes, we examined event-related (de)synchronization processes in theta and alpha-band activity and performed beamforming analyses on the EEG data of previously published behavioral findings. This yielded two possible explanations: There may be a selective decrease of working memory engagement in case of relatively low demand, which boosts response automatization, ultimately putting more strain on the remaining inhibitory resources. Alternatively, there may be a decrease in proactive preparatory and anticipatory attentional gating processes in case of relatively low demand, hindering attentional sampling of upcoming stimuli. Crucially, both of these interrelated mechanisms reflect differential alcohol effects after the actual motor inhibition process and therefore tend to be processes that serve to anticipate future response inhibition affordances. This provides new insights into how high-dose alcohol intoxication can impair inhibitory control.
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spelling pubmed-88611832022-02-23 How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication Stock, Ann-Kathrin Yu, Shijing Ghin, Filippo Beste, Christian Sci Rep Article High-dose alcohol intoxication is commonly associated with impaired inhibition, but the boundary conditions, as well as associated neurocognitive/neuroanatomical changes have remained rather unclear. This study was motivated by the counterintuitive finding that high-dose alcohol intoxication compromises response inhibition performance when working memory demands were low, but not when they were high. To investigate whether this is more likely to be caused by deficits in cognitive control processes or in attentional processes, we examined event-related (de)synchronization processes in theta and alpha-band activity and performed beamforming analyses on the EEG data of previously published behavioral findings. This yielded two possible explanations: There may be a selective decrease of working memory engagement in case of relatively low demand, which boosts response automatization, ultimately putting more strain on the remaining inhibitory resources. Alternatively, there may be a decrease in proactive preparatory and anticipatory attentional gating processes in case of relatively low demand, hindering attentional sampling of upcoming stimuli. Crucially, both of these interrelated mechanisms reflect differential alcohol effects after the actual motor inhibition process and therefore tend to be processes that serve to anticipate future response inhibition affordances. This provides new insights into how high-dose alcohol intoxication can impair inhibitory control. Nature Publishing Group UK 2022-02-21 /pmc/articles/PMC8861183/ /pubmed/35190563 http://dx.doi.org/10.1038/s41598-022-06517-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Stock, Ann-Kathrin
Yu, Shijing
Ghin, Filippo
Beste, Christian
How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title_full How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title_fullStr How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title_full_unstemmed How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title_short How low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
title_sort how low working memory demands and reduced anticipatory attentional gating contribute to impaired inhibition during acute alcohol intoxication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861183/
https://www.ncbi.nlm.nih.gov/pubmed/35190563
http://dx.doi.org/10.1038/s41598-022-06517-9
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