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Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861352/ https://www.ncbi.nlm.nih.gov/pubmed/35211458 http://dx.doi.org/10.3389/fchem.2021.792810 |
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author | Xiao, Na Xu, Yiru Zhang, Xinru Li, Haonan Zhang, Shengnan Xiao, Ang Yu, Jinyi Yang, Mingtian Lv, Fujin Zhang, Mingyu Hao, Gangping Chen, Guotong Zhou, Liman Kong, Fandong Pan, Guojun |
author_facet | Xiao, Na Xu, Yiru Zhang, Xinru Li, Haonan Zhang, Shengnan Xiao, Ang Yu, Jinyi Yang, Mingtian Lv, Fujin Zhang, Mingyu Hao, Gangping Chen, Guotong Zhou, Liman Kong, Fandong Pan, Guojun |
author_sort | Xiao, Na |
collection | PubMed |
description | Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (1–5), named encindolenes D-H, were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds 1–5 could inhibit the hepatic glucose production with EC(50) values of 17.6, 30.1, 21.3, 9.6, and 9.9 μM, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells. |
format | Online Article Text |
id | pubmed-8861352 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88613522022-02-23 Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne Xiao, Na Xu, Yiru Zhang, Xinru Li, Haonan Zhang, Shengnan Xiao, Ang Yu, Jinyi Yang, Mingtian Lv, Fujin Zhang, Mingyu Hao, Gangping Chen, Guotong Zhou, Liman Kong, Fandong Pan, Guojun Front Chem Chemistry Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (1–5), named encindolenes D-H, were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds 1–5 could inhibit the hepatic glucose production with EC(50) values of 17.6, 30.1, 21.3, 9.6, and 9.9 μM, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells. Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8861352/ /pubmed/35211458 http://dx.doi.org/10.3389/fchem.2021.792810 Text en Copyright © 2022 Xiao, Xu, Zhang, Li, Zhang, Xiao, Yu, Yang, Lv, Zhang, Hao, Chen, Zhou, Kong and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Xiao, Na Xu, Yiru Zhang, Xinru Li, Haonan Zhang, Shengnan Xiao, Ang Yu, Jinyi Yang, Mingtian Lv, Fujin Zhang, Mingyu Hao, Gangping Chen, Guotong Zhou, Liman Kong, Fandong Pan, Guojun Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title | Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title_full | Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title_fullStr | Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title_full_unstemmed | Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title_short | Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne |
title_sort | anti-diabetic indole-terpenoids from penicillium sp. hff16 isolated from the rhizosphere soil of cynanchum bungei decne |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861352/ https://www.ncbi.nlm.nih.gov/pubmed/35211458 http://dx.doi.org/10.3389/fchem.2021.792810 |
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