Cargando…

Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne

Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiao, Na, Xu, Yiru, Zhang, Xinru, Li, Haonan, Zhang, Shengnan, Xiao, Ang, Yu, Jinyi, Yang, Mingtian, Lv, Fujin, Zhang, Mingyu, Hao, Gangping, Chen, Guotong, Zhou, Liman, Kong, Fandong, Pan, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861352/
https://www.ncbi.nlm.nih.gov/pubmed/35211458
http://dx.doi.org/10.3389/fchem.2021.792810
_version_ 1784654867221970944
author Xiao, Na
Xu, Yiru
Zhang, Xinru
Li, Haonan
Zhang, Shengnan
Xiao, Ang
Yu, Jinyi
Yang, Mingtian
Lv, Fujin
Zhang, Mingyu
Hao, Gangping
Chen, Guotong
Zhou, Liman
Kong, Fandong
Pan, Guojun
author_facet Xiao, Na
Xu, Yiru
Zhang, Xinru
Li, Haonan
Zhang, Shengnan
Xiao, Ang
Yu, Jinyi
Yang, Mingtian
Lv, Fujin
Zhang, Mingyu
Hao, Gangping
Chen, Guotong
Zhou, Liman
Kong, Fandong
Pan, Guojun
author_sort Xiao, Na
collection PubMed
description Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (1–5), named encindolenes D-H, were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds 1–5 could inhibit the hepatic glucose production with EC(50) values of 17.6, 30.1, 21.3, 9.6, and 9.9 μM, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells.
format Online
Article
Text
id pubmed-8861352
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-88613522022-02-23 Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne Xiao, Na Xu, Yiru Zhang, Xinru Li, Haonan Zhang, Shengnan Xiao, Ang Yu, Jinyi Yang, Mingtian Lv, Fujin Zhang, Mingyu Hao, Gangping Chen, Guotong Zhou, Liman Kong, Fandong Pan, Guojun Front Chem Chemistry Finding novel anti-diabetic compounds with effective suppression activities against hepatic glucagon response is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. As part of our ongoing research, five new indole-terpenoids (1–5), named encindolenes D-H, were isolated from the fungus Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the anti-diabetic activity assay, compounds 1–5 could inhibit the hepatic glucose production with EC(50) values of 17.6, 30.1, 21.3, 9.6, and 9.9 μM, respectively, and decrease the cAMP contents in glucagon-induced HepG2 cells. Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8861352/ /pubmed/35211458 http://dx.doi.org/10.3389/fchem.2021.792810 Text en Copyright © 2022 Xiao, Xu, Zhang, Li, Zhang, Xiao, Yu, Yang, Lv, Zhang, Hao, Chen, Zhou, Kong and Pan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Xiao, Na
Xu, Yiru
Zhang, Xinru
Li, Haonan
Zhang, Shengnan
Xiao, Ang
Yu, Jinyi
Yang, Mingtian
Lv, Fujin
Zhang, Mingyu
Hao, Gangping
Chen, Guotong
Zhou, Liman
Kong, Fandong
Pan, Guojun
Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title_full Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title_fullStr Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title_full_unstemmed Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title_short Anti-Diabetic Indole-Terpenoids From Penicillium sp. HFF16 Isolated From the Rhizosphere Soil of Cynanchum bungei Decne
title_sort anti-diabetic indole-terpenoids from penicillium sp. hff16 isolated from the rhizosphere soil of cynanchum bungei decne
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861352/
https://www.ncbi.nlm.nih.gov/pubmed/35211458
http://dx.doi.org/10.3389/fchem.2021.792810
work_keys_str_mv AT xiaona antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT xuyiru antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT zhangxinru antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT lihaonan antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT zhangshengnan antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT xiaoang antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT yujinyi antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT yangmingtian antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT lvfujin antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT zhangmingyu antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT haogangping antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT chenguotong antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT zhouliman antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT kongfandong antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne
AT panguojun antidiabeticindoleterpenoidsfrompenicilliumsphff16isolatedfromtherhizospheresoilofcynanchumbungeidecne