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Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis

Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous s...

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Autores principales: Hedges, Emily P., Dickson, Hannah, Tognin, Stefania, Modinos, Gemma, Antoniades, Mathilde, van der Gaag, Mark, de Haan, Lieuwe, McGorry, Patrick, Pantelis, Christos, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P., van Os, Jim, Valmaggia, Lucia R., McGuire, Philip, Kempton, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861401/
https://www.ncbi.nlm.nih.gov/pubmed/35242602
http://dx.doi.org/10.1016/j.scog.2021.100222
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author Hedges, Emily P.
Dickson, Hannah
Tognin, Stefania
Modinos, Gemma
Antoniades, Mathilde
van der Gaag, Mark
de Haan, Lieuwe
McGorry, Patrick
Pantelis, Christos
Riecher-Rössler, Anita
Bressan, Rodrigo
Barrantes-Vidal, Neus
Krebs, Marie-Odile
Nordentoft, Merete
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P.
van Os, Jim
Valmaggia, Lucia R.
McGuire, Philip
Kempton, Matthew J.
author_facet Hedges, Emily P.
Dickson, Hannah
Tognin, Stefania
Modinos, Gemma
Antoniades, Mathilde
van der Gaag, Mark
de Haan, Lieuwe
McGorry, Patrick
Pantelis, Christos
Riecher-Rössler, Anita
Bressan, Rodrigo
Barrantes-Vidal, Neus
Krebs, Marie-Odile
Nordentoft, Merete
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P.
van Os, Jim
Valmaggia, Lucia R.
McGuire, Philip
Kempton, Matthew J.
author_sort Hedges, Emily P.
collection PubMed
description Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis.
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spelling pubmed-88614012022-03-02 Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis Hedges, Emily P. Dickson, Hannah Tognin, Stefania Modinos, Gemma Antoniades, Mathilde van der Gaag, Mark de Haan, Lieuwe McGorry, Patrick Pantelis, Christos Riecher-Rössler, Anita Bressan, Rodrigo Barrantes-Vidal, Neus Krebs, Marie-Odile Nordentoft, Merete Ruhrmann, Stephan Sachs, Gabriele Rutten, Bart P. van Os, Jim Valmaggia, Lucia R. McGuire, Philip Kempton, Matthew J. Schizophr Res Cogn Article Robust deficits in cognitive functioning are present in people with psychosis and are evident in the early stages of the disorder. Impairments in verbal memory and verbal fluency are reliably seen in individuals at clinical high-risk for psychosis (CHR) compared to healthy populations. As previous studies have shown a relationship between cognition and longer-term outcomes in schizophrenia, the aim of this paper was to explore whether verbal memory and verbal fluency performance predicted outcomes in a large CHR sample recruited as part of the EU-GEI High Risk Study. Participants included 316 CHR individuals, 90.8% of whom were not currently on antipsychotic medication, and 60 healthy controls. Verbal memory and verbal fluency performance were measured at baseline. At two-year follow-up, CHR individuals were assessed by three different outcome measures, those who did and did not (1) transition to psychosis, (2) experience burdening impairment or disabilities, or (3) remit clinically from CHR status. Individuals with CHR displayed significant verbal memory and verbal fluency deficits at baseline compared to healthy controls (Hedges' g effect size = 0.24 to 0.66). There were no significant differences in cognitive performance of those who did and did not transition to psychosis. However, impaired immediate verbal recall predicted both functional disability and non-remission from the CHR state. Results remained significant when analyses were restricted to only include antipsychotic-free CHR participants. These findings may inform the development of early interventions designed to improve cognitive deficits in the early stages of psychosis. Elsevier 2021-10-28 /pmc/articles/PMC8861401/ /pubmed/35242602 http://dx.doi.org/10.1016/j.scog.2021.100222 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hedges, Emily P.
Dickson, Hannah
Tognin, Stefania
Modinos, Gemma
Antoniades, Mathilde
van der Gaag, Mark
de Haan, Lieuwe
McGorry, Patrick
Pantelis, Christos
Riecher-Rössler, Anita
Bressan, Rodrigo
Barrantes-Vidal, Neus
Krebs, Marie-Odile
Nordentoft, Merete
Ruhrmann, Stephan
Sachs, Gabriele
Rutten, Bart P.
van Os, Jim
Valmaggia, Lucia R.
McGuire, Philip
Kempton, Matthew J.
Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title_full Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title_fullStr Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title_full_unstemmed Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title_short Verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
title_sort verbal memory performance predicts remission and functional outcome in people at clinical high-risk for psychosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861401/
https://www.ncbi.nlm.nih.gov/pubmed/35242602
http://dx.doi.org/10.1016/j.scog.2021.100222
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