Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages

BTB-and-CNC homologue 1 (BACH1), a heme-regulated transcription factor, mediates innate immune responses via its functional role in macrophages. BACH1 has recently been shown to modulate mitochondrial metabolism in cancer cells. In the current study, we utilized a proteomics approach and demonstrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Pradhan, Pooja, Vijayan, Vijith, Cirksena, Karsten, Buettner, Falk F.R., Igarashi, Kazuhiko, Motterlini, Roberto, Foresti, Roberta, Immenschuh, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861416/
https://www.ncbi.nlm.nih.gov/pubmed/35189551
http://dx.doi.org/10.1016/j.redox.2022.102265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861416/
https://www.ncbi.nlm.nih.gov/pubmed/35189551
http://dx.doi.org/10.1016/j.redox.2022.102265

Ejemplares similares