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What Clonal Hematopoiesis Can Teach Us About MDS
Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelody...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861516/ https://www.ncbi.nlm.nih.gov/pubmed/35211401 http://dx.doi.org/10.3389/fonc.2022.794021 |
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author | Chan, Irenaeus C. C. Wiley, Brian J. Bolton, Kelly L. |
author_facet | Chan, Irenaeus C. C. Wiley, Brian J. Bolton, Kelly L. |
author_sort | Chan, Irenaeus C. C. |
collection | PubMed |
description | Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasm (MPN). Recent work has elucidated how the development and cellular fitness of CH is shaped by aging, environmental exposures, and the germline (inherited) genetic background of an individual. This in turn has provided valuable insights into the pathogenesis of MNs including MDS. Here, in this review, we discuss the genetic origins of CH, the environmental stressors that influence CH, and the implications of CH on health outcomes including MDS. Since MNs have shared risk factors and underlying biology, most of our discussion regarding the implications of CH surrounds MN in general rather than focusing specifically on MDS. We conclude with future directions and areas of investigation including how intervention studies of CH might inform future therapeutic approaches to MN including MDS. |
format | Online Article Text |
id | pubmed-8861516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88615162022-02-23 What Clonal Hematopoiesis Can Teach Us About MDS Chan, Irenaeus C. C. Wiley, Brian J. Bolton, Kelly L. Front Oncol Oncology Clonal hematopoiesis (CH), defined as the clonal expansion of mutated hematopoietic stem and progenitor cells (HSPCs), is a common aging process. CH is a risk factor for the development of hematologic malignancies, most commonly myeloid neoplasms (MNs) including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and myeloproliferative neoplasm (MPN). Recent work has elucidated how the development and cellular fitness of CH is shaped by aging, environmental exposures, and the germline (inherited) genetic background of an individual. This in turn has provided valuable insights into the pathogenesis of MNs including MDS. Here, in this review, we discuss the genetic origins of CH, the environmental stressors that influence CH, and the implications of CH on health outcomes including MDS. Since MNs have shared risk factors and underlying biology, most of our discussion regarding the implications of CH surrounds MN in general rather than focusing specifically on MDS. We conclude with future directions and areas of investigation including how intervention studies of CH might inform future therapeutic approaches to MN including MDS. Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8861516/ /pubmed/35211401 http://dx.doi.org/10.3389/fonc.2022.794021 Text en Copyright © 2022 Chan, Wiley and Bolton https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chan, Irenaeus C. C. Wiley, Brian J. Bolton, Kelly L. What Clonal Hematopoiesis Can Teach Us About MDS |
title | What Clonal Hematopoiesis Can Teach Us About MDS |
title_full | What Clonal Hematopoiesis Can Teach Us About MDS |
title_fullStr | What Clonal Hematopoiesis Can Teach Us About MDS |
title_full_unstemmed | What Clonal Hematopoiesis Can Teach Us About MDS |
title_short | What Clonal Hematopoiesis Can Teach Us About MDS |
title_sort | what clonal hematopoiesis can teach us about mds |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861516/ https://www.ncbi.nlm.nih.gov/pubmed/35211401 http://dx.doi.org/10.3389/fonc.2022.794021 |
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