Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies

As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template. Of the 11 DHIT derivatives synthesized using a Knoeve...

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Detalles Bibliográficos
Autores principales: Choi, Heejeong, Young Ryu, Il, Choi, Inkyu, Ullah, Sultan, Jin Jung, Hee, Park, Yujin, Hwang, YeJi, Jeong, Yeongmu, Hong, Sojeong, Chun, Pusoon, Young Chung, Hae, Ryong Moon, Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861568/
https://www.ncbi.nlm.nih.gov/pubmed/35242283
http://dx.doi.org/10.1016/j.csbj.2022.02.007

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