Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I

Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a crucial enzyme in energy metabolism, captures the redox potential energy from NADH oxidation/ubiquinone reduction to create the proton motive force used to drive ATP synthesis in oxidative phosphorylation. High-resolution single-particle el...

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Detalles Bibliográficos
Autores principales: Grba, Daniel N., Blaza, James N., Bridges, Hannah R., Agip, Ahmed-Noor A., Yin, Zhan, Murai, Masatoshi, Miyoshi, Hideto, Hirst, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861642/
https://www.ncbi.nlm.nih.gov/pubmed/35063503
http://dx.doi.org/10.1016/j.jbc.2022.101602

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