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A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection
Malectins from the oligosaccharyltransferase (OST) complex in the endoplasmic reticulum (ER) of animal cells are involved in ER quality control and contribute to the Unfolded Protein Response (UPR). Malectins are not found in plant cells, but malectin-like domains (MLDs) are constituents of many mem...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861646/ https://www.ncbi.nlm.nih.gov/pubmed/35243239 http://dx.doi.org/10.1016/j.isci.2022.103877 |
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author | Giordano, Laïla Allasia, Valérie Cremades, Alexandra Hok, Sophie Panabières, Franck Bailly-Maître, Béatrice Keller, Harald |
author_facet | Giordano, Laïla Allasia, Valérie Cremades, Alexandra Hok, Sophie Panabières, Franck Bailly-Maître, Béatrice Keller, Harald |
author_sort | Giordano, Laïla |
collection | PubMed |
description | Malectins from the oligosaccharyltransferase (OST) complex in the endoplasmic reticulum (ER) of animal cells are involved in ER quality control and contribute to the Unfolded Protein Response (UPR). Malectins are not found in plant cells, but malectin-like domains (MLDs) are constituents of many membrane-bound receptors. In Arabidopsis thaliana, the MLD-containing receptor IOS1 promotes successful infection by filamentous plant pathogens. We show that the MLD of its exodomain retains IOS1 in the ER of plant cells and attenuates the infection-induced UPR. Expression of the MLD in the ios1-1 knockout background is sufficient to complement infection-related phenotypes of the mutant, such as increased UPR and reduced disease susceptibility. IOS1 interacts with the ER membrane-associated ribophorin HAP6 from the OST complex, and hap6 mutants show decreased pathogen-responsive UPR and increased disease susceptibility. Altogether, this study revealed a previously uncharacterized role of a plant receptor domain in the regulation of ER stress during infection. |
format | Online Article Text |
id | pubmed-8861646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88616462022-03-02 A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection Giordano, Laïla Allasia, Valérie Cremades, Alexandra Hok, Sophie Panabières, Franck Bailly-Maître, Béatrice Keller, Harald iScience Article Malectins from the oligosaccharyltransferase (OST) complex in the endoplasmic reticulum (ER) of animal cells are involved in ER quality control and contribute to the Unfolded Protein Response (UPR). Malectins are not found in plant cells, but malectin-like domains (MLDs) are constituents of many membrane-bound receptors. In Arabidopsis thaliana, the MLD-containing receptor IOS1 promotes successful infection by filamentous plant pathogens. We show that the MLD of its exodomain retains IOS1 in the ER of plant cells and attenuates the infection-induced UPR. Expression of the MLD in the ios1-1 knockout background is sufficient to complement infection-related phenotypes of the mutant, such as increased UPR and reduced disease susceptibility. IOS1 interacts with the ER membrane-associated ribophorin HAP6 from the OST complex, and hap6 mutants show decreased pathogen-responsive UPR and increased disease susceptibility. Altogether, this study revealed a previously uncharacterized role of a plant receptor domain in the regulation of ER stress during infection. Elsevier 2022-02-05 /pmc/articles/PMC8861646/ /pubmed/35243239 http://dx.doi.org/10.1016/j.isci.2022.103877 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Giordano, Laïla Allasia, Valérie Cremades, Alexandra Hok, Sophie Panabières, Franck Bailly-Maître, Béatrice Keller, Harald A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title | A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title_full | A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title_fullStr | A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title_full_unstemmed | A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title_short | A plant receptor domain with functional analogies to animal malectin disables ER stress responses upon infection |
title_sort | plant receptor domain with functional analogies to animal malectin disables er stress responses upon infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861646/ https://www.ncbi.nlm.nih.gov/pubmed/35243239 http://dx.doi.org/10.1016/j.isci.2022.103877 |
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