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A design principle of spindle oscillations in mammalian sleep

Neural oscillations are mainly regulated by molecular mechanisms and network connectivity of neurons. Large-scale simulations of neuronal networks have driven the population-level understanding of neural oscillations. However, cell-intrinsic mechanisms, especially a design principle, of neural oscil...

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Detalles Bibliográficos
Autores principales: Yamada, Tetsuya, Shi, Shoi, Ueda, Hiroki R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861656/
https://www.ncbi.nlm.nih.gov/pubmed/35243235
http://dx.doi.org/10.1016/j.isci.2022.103873
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author Yamada, Tetsuya
Shi, Shoi
Ueda, Hiroki R.
author_facet Yamada, Tetsuya
Shi, Shoi
Ueda, Hiroki R.
author_sort Yamada, Tetsuya
collection PubMed
description Neural oscillations are mainly regulated by molecular mechanisms and network connectivity of neurons. Large-scale simulations of neuronal networks have driven the population-level understanding of neural oscillations. However, cell-intrinsic mechanisms, especially a design principle, of neural oscillations remain largely elusive. Herein, we developed a minimal, Hodgkin-Huxley-type model of groups of neurons to investigate molecular mechanisms underlying spindle oscillation, which is synchronized oscillatory activity predominantly observed during mammalian sleep. We discovered that slowly inactivating potassium channels played an essential role in characterizing the firing pattern. The detailed analysis of the minimal model revealed that leak sodium and potassium channels, which controlled passive properties of the fast variable (i.e., membrane potential), competitively regulated the base value and time constant of the slow variable (i.e., cytosolic calcium concentration). Consequently, we propose a theoretical design principle of spindle oscillations that may explain intracellular mechanisms behind the flexible control over oscillation density and calcium setpoint.
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spelling pubmed-88616562022-03-02 A design principle of spindle oscillations in mammalian sleep Yamada, Tetsuya Shi, Shoi Ueda, Hiroki R. iScience Article Neural oscillations are mainly regulated by molecular mechanisms and network connectivity of neurons. Large-scale simulations of neuronal networks have driven the population-level understanding of neural oscillations. However, cell-intrinsic mechanisms, especially a design principle, of neural oscillations remain largely elusive. Herein, we developed a minimal, Hodgkin-Huxley-type model of groups of neurons to investigate molecular mechanisms underlying spindle oscillation, which is synchronized oscillatory activity predominantly observed during mammalian sleep. We discovered that slowly inactivating potassium channels played an essential role in characterizing the firing pattern. The detailed analysis of the minimal model revealed that leak sodium and potassium channels, which controlled passive properties of the fast variable (i.e., membrane potential), competitively regulated the base value and time constant of the slow variable (i.e., cytosolic calcium concentration). Consequently, we propose a theoretical design principle of spindle oscillations that may explain intracellular mechanisms behind the flexible control over oscillation density and calcium setpoint. Elsevier 2022-02-05 /pmc/articles/PMC8861656/ /pubmed/35243235 http://dx.doi.org/10.1016/j.isci.2022.103873 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yamada, Tetsuya
Shi, Shoi
Ueda, Hiroki R.
A design principle of spindle oscillations in mammalian sleep
title A design principle of spindle oscillations in mammalian sleep
title_full A design principle of spindle oscillations in mammalian sleep
title_fullStr A design principle of spindle oscillations in mammalian sleep
title_full_unstemmed A design principle of spindle oscillations in mammalian sleep
title_short A design principle of spindle oscillations in mammalian sleep
title_sort design principle of spindle oscillations in mammalian sleep
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861656/
https://www.ncbi.nlm.nih.gov/pubmed/35243235
http://dx.doi.org/10.1016/j.isci.2022.103873
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