Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Immune checkpoint blockade (CPB) improves melanoma outcomes, but many patients still do not respond. Tumor mutational burden (TMB) and tumor-infiltrating T cells are associated with response, and integrative models improve survival prediction. However, integrating immune/tumor-intrinsic features usi...

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Detalles Bibliográficos
Autores principales: Freeman, Samuel S., Sade-Feldman, Moshe, Kim, Jaegil, Stewart, Chip, Gonye, Anna L.K., Ravi, Arvind, Arniella, Monica B., Gushterova, Irena, LaSalle, Thomas J., Blaum, Emily M., Yizhak, Keren, Frederick, Dennie T., Sharova, Tatyana, Leshchiner, Ignaty, Elagina, Liudmila, Spiro, Oliver G., Livitz, Dimitri, Rosebrock, Daniel, Aguet, François, Carrot-Zhang, Jian, Ha, Gavin, Lin, Ziao, Chen, Jonathan H., Barzily-Rokni, Michal, Hammond, Marc R., Vitzthum von Eckstaedt, Hans C., Blackmon, Shauna M., Jiao, Yunxin J., Gabriel, Stacey, Lawrence, Donald P., Duncan, Lyn M., Stemmer-Rachamimov, Anat O., Wargo, Jennifer A., Flaherty, Keith T., Sullivan, Ryan J., Boland, Genevieve M., Meyerson, Matthew, Getz, Gad, Hacohen, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861826/
https://www.ncbi.nlm.nih.gov/pubmed/35243413
http://dx.doi.org/10.1016/j.xcrm.2021.100500

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