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Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment

During this last decade, adoptive transfer of T lymphocytes genetically modified to express chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in hematological cancers. However, this immunotherapy has demonstrated limited efficacy in solid tumors. The main obstacle encounte...

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Detalles Bibliográficos
Autores principales:	Andrea, Alain E., Chiron, Andrada, Mallah, Sarah, Bessoles, Stéphanie, Sarrabayrouse, Guillaume, Hacein-Bey-Abina, Salima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861853/ https://www.ncbi.nlm.nih.gov/pubmed/35211124 http://dx.doi.org/10.3389/fimmu.2022.830292

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