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Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019

OBJECTIVE: Due to increased use of pre-exposure prohylaxis (PrEP) and its potential to affect HIV screening of blood donors, we undertook antiretroviral residual testing among HIV-negative male donors in England. METHODS: Residual plasma samples were obtainnd from 46 male donors confirmed positive f...

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Autores principales: Harvala, Heli, Reynolds, Claire, Ijaz, Samreen, Maddox, Vicki, Penchala, Sujan Dilly, Amara, Alieu, Else, Laura, Brailsford, Susan, Khoo, Saye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862030/
https://www.ncbi.nlm.nih.gov/pubmed/33782147
http://dx.doi.org/10.1136/sextrans-2021-054981
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author Harvala, Heli
Reynolds, Claire
Ijaz, Samreen
Maddox, Vicki
Penchala, Sujan Dilly
Amara, Alieu
Else, Laura
Brailsford, Susan
Khoo, Saye
author_facet Harvala, Heli
Reynolds, Claire
Ijaz, Samreen
Maddox, Vicki
Penchala, Sujan Dilly
Amara, Alieu
Else, Laura
Brailsford, Susan
Khoo, Saye
author_sort Harvala, Heli
collection PubMed
description OBJECTIVE: Due to increased use of pre-exposure prohylaxis (PrEP) and its potential to affect HIV screening of blood donors, we undertook antiretroviral residual testing among HIV-negative male donors in England. METHODS: Residual plasma samples were obtainnd from 46 male donors confirmed positive for syphilis and 96 donors who were repeat reactive for HIV antibodies in screening but confirmed as HIV-negative by reference testing. These were tested for concentrations of tenofovir and emtricitabine by high-performance liquid chromatograhpy coupled with mass spectrometry. RESULTS: We found evidence of pre-exposure or post-exposure prophylaxis (PrEP/PEP) use in three male blood donors confirmed positive for syphilis (3 out of 46 screened, 6.5%). Two were estimated to have taken PrEP/PEP within a day of donating, and the third within 2 days. Two were new donors, whereas one had donated previously but acquired syphilis infection after his last donation. CONCLUSIONS: Our findings indicate that a small proportion of blood donors have not been disclosing PrEP/PEP use and therefore donating in non-compliance to donor eligibility criteria.
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spelling pubmed-88620302022-03-15 Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019 Harvala, Heli Reynolds, Claire Ijaz, Samreen Maddox, Vicki Penchala, Sujan Dilly Amara, Alieu Else, Laura Brailsford, Susan Khoo, Saye Sex Transm Infect Health Services Research OBJECTIVE: Due to increased use of pre-exposure prohylaxis (PrEP) and its potential to affect HIV screening of blood donors, we undertook antiretroviral residual testing among HIV-negative male donors in England. METHODS: Residual plasma samples were obtainnd from 46 male donors confirmed positive for syphilis and 96 donors who were repeat reactive for HIV antibodies in screening but confirmed as HIV-negative by reference testing. These were tested for concentrations of tenofovir and emtricitabine by high-performance liquid chromatograhpy coupled with mass spectrometry. RESULTS: We found evidence of pre-exposure or post-exposure prophylaxis (PrEP/PEP) use in three male blood donors confirmed positive for syphilis (3 out of 46 screened, 6.5%). Two were estimated to have taken PrEP/PEP within a day of donating, and the third within 2 days. Two were new donors, whereas one had donated previously but acquired syphilis infection after his last donation. CONCLUSIONS: Our findings indicate that a small proportion of blood donors have not been disclosing PrEP/PEP use and therefore donating in non-compliance to donor eligibility criteria. BMJ Publishing Group 2022-03 2021-03-29 /pmc/articles/PMC8862030/ /pubmed/33782147 http://dx.doi.org/10.1136/sextrans-2021-054981 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Health Services Research
Harvala, Heli
Reynolds, Claire
Ijaz, Samreen
Maddox, Vicki
Penchala, Sujan Dilly
Amara, Alieu
Else, Laura
Brailsford, Susan
Khoo, Saye
Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title_full Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title_fullStr Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title_full_unstemmed Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title_short Evidence of HIV pre-exposure or post-exposure prophylaxis (PrEP/PEP) among blood donors: a pilot study, England June 2018 to July 2019
title_sort evidence of hiv pre-exposure or post-exposure prophylaxis (prep/pep) among blood donors: a pilot study, england june 2018 to july 2019
topic Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862030/
https://www.ncbi.nlm.nih.gov/pubmed/33782147
http://dx.doi.org/10.1136/sextrans-2021-054981
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