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Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab
Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862033/ https://www.ncbi.nlm.nih.gov/pubmed/35211311 http://dx.doi.org/10.1093/ckj/sfab250 |
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author | Ginthör, Noemi E Artinger, Katharina Pollheimer, Marion J Stradner, Martin H Eller, Kathrin |
author_facet | Ginthör, Noemi E Artinger, Katharina Pollheimer, Marion J Stradner, Martin H Eller, Kathrin |
author_sort | Ginthör, Noemi E |
collection | PubMed |
description | Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab. |
format | Online Article Text |
id | pubmed-8862033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88620332022-02-23 Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab Ginthör, Noemi E Artinger, Katharina Pollheimer, Marion J Stradner, Martin H Eller, Kathrin Clin Kidney J Exceptional Case Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab. Oxford University Press 2021-12-08 /pmc/articles/PMC8862033/ /pubmed/35211311 http://dx.doi.org/10.1093/ckj/sfab250 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Exceptional Case Ginthör, Noemi E Artinger, Katharina Pollheimer, Marion J Stradner, Martin H Eller, Kathrin Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title | Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title_full | Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title_fullStr | Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title_full_unstemmed | Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title_short | Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab |
title_sort | membranous nephropathy associated with immunoglobulin g4-related disease successfully treated with obinutuzumab |
topic | Exceptional Case |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862033/ https://www.ncbi.nlm.nih.gov/pubmed/35211311 http://dx.doi.org/10.1093/ckj/sfab250 |
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