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Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice

OBJECTIVE: To investigate the abundance and the prevalence of Dysosmobacter welbionis J115(T), a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study the impact of this bacterium on host metabolism using diet-...

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Autores principales: Le Roy, Tiphaine, Moens de Hase, Emilie, Van Hul, Matthias, Paquot, Adrien, Pelicaen, Rudy, Régnier, Marion, Depommier, Clara, Druart, Céline, Everard, Amandine, Maiter, Dominique, Delzenne, Nathalie M, Bindels, Laure B, de Barsy, Marie, Loumaye, Audrey, Hermans, Michel P, Thissen, Jean-Paul, Vieira-Silva, Sara, Falony, Gwen, Raes, Jeroen, Muccioli, Giulio G, Cani, Patrice D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862106/
https://www.ncbi.nlm.nih.gov/pubmed/34108237
http://dx.doi.org/10.1136/gutjnl-2020-323778
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author Le Roy, Tiphaine
Moens de Hase, Emilie
Van Hul, Matthias
Paquot, Adrien
Pelicaen, Rudy
Régnier, Marion
Depommier, Clara
Druart, Céline
Everard, Amandine
Maiter, Dominique
Delzenne, Nathalie M
Bindels, Laure B
de Barsy, Marie
Loumaye, Audrey
Hermans, Michel P
Thissen, Jean-Paul
Vieira-Silva, Sara
Falony, Gwen
Raes, Jeroen
Muccioli, Giulio G
Cani, Patrice D
author_facet Le Roy, Tiphaine
Moens de Hase, Emilie
Van Hul, Matthias
Paquot, Adrien
Pelicaen, Rudy
Régnier, Marion
Depommier, Clara
Druart, Céline
Everard, Amandine
Maiter, Dominique
Delzenne, Nathalie M
Bindels, Laure B
de Barsy, Marie
Loumaye, Audrey
Hermans, Michel P
Thissen, Jean-Paul
Vieira-Silva, Sara
Falony, Gwen
Raes, Jeroen
Muccioli, Giulio G
Cani, Patrice D
author_sort Le Roy, Tiphaine
collection PubMed
description OBJECTIVE: To investigate the abundance and the prevalence of Dysosmobacter welbionis J115(T), a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study the impact of this bacterium on host metabolism using diet-induced obese and diabetic mice. DESIGN: We analysed the presence and abundance of the bacterium in 11 984 subjects using four human cohorts (ie, Human Microbiome Project, American Gut Project, Flemish Gut Flora Project and Microbes4U). Then, we tested the effects of daily oral gavages with live D. welbionis J115(T) on metabolism and several hallmarks of obesity, diabetes, inflammation and lipid metabolism in obese/diabetic mice. RESULTS: This newly identified bacterium was detected in 62.7%–69.8% of the healthy population. Strikingly, in obese humans with a metabolic syndrome, the abundance of Dysosmobacter genus correlates negatively with body mass index, fasting glucose and glycated haemoglobin. In mice, supplementation with live D. welbionis J115(T), but not with the pasteurised bacteria, partially counteracted diet-induced obesity development, fat mass gain, insulin resistance and white adipose tissue hypertrophy and inflammation. In addition, live D. welbionis J115(T) administration protected the mice from brown adipose tissue inflammation in association with increased mitochondria number and non-shivering thermogenesis. These effects occurred with minor impact on the mouse intestinal microbiota composition. CONCLUSIONS: These results suggest that D. welbionis J115(T) directly and beneficially influences host metabolism and is a strong candidate for the development of next-generation beneficial bacteria targeting obesity and associated metabolic diseases.
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spelling pubmed-88621062022-03-15 Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice Le Roy, Tiphaine Moens de Hase, Emilie Van Hul, Matthias Paquot, Adrien Pelicaen, Rudy Régnier, Marion Depommier, Clara Druart, Céline Everard, Amandine Maiter, Dominique Delzenne, Nathalie M Bindels, Laure B de Barsy, Marie Loumaye, Audrey Hermans, Michel P Thissen, Jean-Paul Vieira-Silva, Sara Falony, Gwen Raes, Jeroen Muccioli, Giulio G Cani, Patrice D Gut Gut Microbiota OBJECTIVE: To investigate the abundance and the prevalence of Dysosmobacter welbionis J115(T), a novel butyrate-producing bacterium isolated from the human gut both in the general population and in subjects with metabolic syndrome. To study the impact of this bacterium on host metabolism using diet-induced obese and diabetic mice. DESIGN: We analysed the presence and abundance of the bacterium in 11 984 subjects using four human cohorts (ie, Human Microbiome Project, American Gut Project, Flemish Gut Flora Project and Microbes4U). Then, we tested the effects of daily oral gavages with live D. welbionis J115(T) on metabolism and several hallmarks of obesity, diabetes, inflammation and lipid metabolism in obese/diabetic mice. RESULTS: This newly identified bacterium was detected in 62.7%–69.8% of the healthy population. Strikingly, in obese humans with a metabolic syndrome, the abundance of Dysosmobacter genus correlates negatively with body mass index, fasting glucose and glycated haemoglobin. In mice, supplementation with live D. welbionis J115(T), but not with the pasteurised bacteria, partially counteracted diet-induced obesity development, fat mass gain, insulin resistance and white adipose tissue hypertrophy and inflammation. In addition, live D. welbionis J115(T) administration protected the mice from brown adipose tissue inflammation in association with increased mitochondria number and non-shivering thermogenesis. These effects occurred with minor impact on the mouse intestinal microbiota composition. CONCLUSIONS: These results suggest that D. welbionis J115(T) directly and beneficially influences host metabolism and is a strong candidate for the development of next-generation beneficial bacteria targeting obesity and associated metabolic diseases. BMJ Publishing Group 2022-03 2021-06-08 /pmc/articles/PMC8862106/ /pubmed/34108237 http://dx.doi.org/10.1136/gutjnl-2020-323778 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Gut Microbiota
Le Roy, Tiphaine
Moens de Hase, Emilie
Van Hul, Matthias
Paquot, Adrien
Pelicaen, Rudy
Régnier, Marion
Depommier, Clara
Druart, Céline
Everard, Amandine
Maiter, Dominique
Delzenne, Nathalie M
Bindels, Laure B
de Barsy, Marie
Loumaye, Audrey
Hermans, Michel P
Thissen, Jean-Paul
Vieira-Silva, Sara
Falony, Gwen
Raes, Jeroen
Muccioli, Giulio G
Cani, Patrice D
Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title_full Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title_fullStr Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title_full_unstemmed Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title_short Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
title_sort dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
topic Gut Microbiota
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862106/
https://www.ncbi.nlm.nih.gov/pubmed/34108237
http://dx.doi.org/10.1136/gutjnl-2020-323778
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