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Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death

Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new donor category. We studied 58 kidney recipients from...

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Autores principales: Gregorini, Marilena, Ticozzelli, Elena, Abelli, Massimo, Grignano, Maria A., Pattonieri, Eleonora F., Giacomoni, Alessandro, De Carlis, Luciano, Dell’Acqua, Antonio, Caldara, Rossana, Socci, Carlo, Bottazzi, Andrea, Libetta, Carmelo, Sepe, Vincenzo, Malabarba, Stefano, Manzoni, Federica, Klersy, Catherine, Piccolo, Giuseppe, Rampino, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862176/
https://www.ncbi.nlm.nih.gov/pubmed/35210934
http://dx.doi.org/10.3389/ti.2021.10179
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author Gregorini, Marilena
Ticozzelli, Elena
Abelli, Massimo
Grignano, Maria A.
Pattonieri, Eleonora F.
Giacomoni, Alessandro
De Carlis, Luciano
Dell’Acqua, Antonio
Caldara, Rossana
Socci, Carlo
Bottazzi, Andrea
Libetta, Carmelo
Sepe, Vincenzo
Malabarba, Stefano
Manzoni, Federica
Klersy, Catherine
Piccolo, Giuseppe
Rampino, Teresa
author_facet Gregorini, Marilena
Ticozzelli, Elena
Abelli, Massimo
Grignano, Maria A.
Pattonieri, Eleonora F.
Giacomoni, Alessandro
De Carlis, Luciano
Dell’Acqua, Antonio
Caldara, Rossana
Socci, Carlo
Bottazzi, Andrea
Libetta, Carmelo
Sepe, Vincenzo
Malabarba, Stefano
Manzoni, Federica
Klersy, Catherine
Piccolo, Giuseppe
Rampino, Teresa
author_sort Gregorini, Marilena
collection PubMed
description Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new donor category. We studied 58 kidney recipients from DCD or EPD and collected donor/recipient clinical characteristics. Primary non function (PNF) and delayed graft function (DGF) rates, dialysis need, hospitalization duration, and patient and graft survival rates were compared. The estimated glomerular filtration rate (eGFR) was measured throughout the follow-up. Better clinical outcomes were achieved with EPD than with DCD despite similar graft and patient survival rates The total warm ischemia time (WIT) was longer in the DCD group than in the EPD group. Pure WIT was the highest in the class II group. The DGF rate was higher in the DCD group than in the EPD group. PNF rate was similar in the groups. Dialysis need was the greatest and hospitalization the longest in the class II DCD group. eGFR was lower in the class II DCD group than in the EPD group. Our results indicate good clinical outcomes of kidney transplants from DCD despite the long “no-touch period” and show that ECMO in the procurement phase improves graft outcome, suggesting EPD as a source for pool expansion.
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spelling pubmed-88621762022-02-23 Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death Gregorini, Marilena Ticozzelli, Elena Abelli, Massimo Grignano, Maria A. Pattonieri, Eleonora F. Giacomoni, Alessandro De Carlis, Luciano Dell’Acqua, Antonio Caldara, Rossana Socci, Carlo Bottazzi, Andrea Libetta, Carmelo Sepe, Vincenzo Malabarba, Stefano Manzoni, Federica Klersy, Catherine Piccolo, Giuseppe Rampino, Teresa Transpl Int Health Archive Donation after circulatory death (DCD) allows expansion of the donor pool. We report on 11 years of Italian experience by comparing the outcome of grafts from DCD and extracorporeal membrane oxygenation (ECMO) prior to death donation (EPD), a new donor category. We studied 58 kidney recipients from DCD or EPD and collected donor/recipient clinical characteristics. Primary non function (PNF) and delayed graft function (DGF) rates, dialysis need, hospitalization duration, and patient and graft survival rates were compared. The estimated glomerular filtration rate (eGFR) was measured throughout the follow-up. Better clinical outcomes were achieved with EPD than with DCD despite similar graft and patient survival rates The total warm ischemia time (WIT) was longer in the DCD group than in the EPD group. Pure WIT was the highest in the class II group. The DGF rate was higher in the DCD group than in the EPD group. PNF rate was similar in the groups. Dialysis need was the greatest and hospitalization the longest in the class II DCD group. eGFR was lower in the class II DCD group than in the EPD group. Our results indicate good clinical outcomes of kidney transplants from DCD despite the long “no-touch period” and show that ECMO in the procurement phase improves graft outcome, suggesting EPD as a source for pool expansion. Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8862176/ /pubmed/35210934 http://dx.doi.org/10.3389/ti.2021.10179 Text en Copyright © 2022 Gregorini, Ticozzelli, Abelli, Grignano, Pattonieri, Giacomoni, De Carlis, Dell’Acqua, Caldara, Socci, Bottazzi, Libetta, Sepe, Malabarba, Manzoni, Klersy, Piccolo and Rampino. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Health Archive
Gregorini, Marilena
Ticozzelli, Elena
Abelli, Massimo
Grignano, Maria A.
Pattonieri, Eleonora F.
Giacomoni, Alessandro
De Carlis, Luciano
Dell’Acqua, Antonio
Caldara, Rossana
Socci, Carlo
Bottazzi, Andrea
Libetta, Carmelo
Sepe, Vincenzo
Malabarba, Stefano
Manzoni, Federica
Klersy, Catherine
Piccolo, Giuseppe
Rampino, Teresa
Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title_full Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title_fullStr Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title_full_unstemmed Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title_short Kidney Transplants From Donors on Extracorporeal Membrane Oxygenation Prior to Death Are Associated With Better Long-Term Renal Function Compared to Donors After Circulatory Death
title_sort kidney transplants from donors on extracorporeal membrane oxygenation prior to death are associated with better long-term renal function compared to donors after circulatory death
topic Health Archive
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862176/
https://www.ncbi.nlm.nih.gov/pubmed/35210934
http://dx.doi.org/10.3389/ti.2021.10179
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