Mutant NPM1-Regulated FTO-Mediated m(6)A Demethylation Promotes Leukemic Cell Survival via PDGFRB/ERK Signaling Axis

Acute myeloid leukemia (AML) with nucleophosmin 1 (NPM1) mutations exhibits distinct biological and clinical features, accounting for approximately one-third of AML. Recently, the N(6)-methyladenosine (m(6)A) RNA modification has emerged as a new epigenetic modification to contribute to tumorigenesi...

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Detalles Bibliográficos
Autores principales: Xiao, Qiaoling, Lei, Li, Ren, Jun, Peng, Meixi, Jing, Yipei, Jiang, Xueke, Huang, Junpeng, Tao, Yonghong, Lin, Can, Yang, Jing, Sun, Minghui, Tang, Lisha, Wei, Xingyu, Yang, Zailin, Zhang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862181/
https://www.ncbi.nlm.nih.gov/pubmed/35211409
http://dx.doi.org/10.3389/fonc.2022.817584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862181/
https://www.ncbi.nlm.nih.gov/pubmed/35211409
http://dx.doi.org/10.3389/fonc.2022.817584

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