Gut- and oral-dysbiosis differentially impact spinal- and bulbar-onset ALS, predicting ALS severity and potentially determining the location of disease onset

BACKGROUND: Prior studies on the role of gut-microbiome in Amyotrophic Lateral Sclerosis (ALS) pathogenesis have yielded conflicting results. We hypothesized that gut- and oral-microbiome may differentially impact two clinically-distinct ALS subtypes (spinal-onset ALS (sALS) vs. bulbar-onset ALS (bA...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Harper S., Son, John, Lee, Donghwan, Tsai, Joy, Wang, Danny, Chocron, E. Sandra, Jeong, Seongwoo, Kittrell, Pamela, Murchison, Charles F., Kennedy, Richard E., Tobon, Alejandro, Jackson, Carlayne E., Pickering, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862222/
https://www.ncbi.nlm.nih.gov/pubmed/35189854
http://dx.doi.org/10.1186/s12883-022-02586-5

Ejemplares similares

Ejemplares similares