Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

BACKGROUND: Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial neoplasia (PanIN) precancerous lesions in mice. However, only...

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Detalles Bibliográficos
Autores principales: Zhang, Anni M. Y., Chu, Ken H., Daly, Brian F., Ruiter, Titine, Dou, Yan, Yang, Jenny C. C., de Winter, Twan J. J., Chhuor, Justin, Wang, Su, Flibotte, Stephane, Zhao, Yiwei Bernie, Hu, Xiaoke, Li, Hong, Rideout, Elizabeth J., Schaeffer, David F., Johnson, James D., Kopp, Janel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862319/
https://www.ncbi.nlm.nih.gov/pubmed/35189981
http://dx.doi.org/10.1186/s40170-022-00282-z

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