Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19

Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neurop...

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Detalles Bibliográficos
Autores principales: Apple, Alexandra C., Oddi, Alexis, Peluso, Michael J., Asken, Breton M., Henrich, Timothy J., Kelly, J. Daniel, Pleasure, Samuel J., Deeks, Steven G., Allen, Isabel Elaine, Martin, Jeffrey N., Ndhlovu, Lishomwa C., Miller, Bruce L., Stephens, Melanie L., Hellmuth, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862406/
https://www.ncbi.nlm.nih.gov/pubmed/35043593
http://dx.doi.org/10.1002/acn3.51498
Descripción
Sumario:Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.

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