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Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19

Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neurop...

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Autores principales: Apple, Alexandra C., Oddi, Alexis, Peluso, Michael J., Asken, Breton M., Henrich, Timothy J., Kelly, J. Daniel, Pleasure, Samuel J., Deeks, Steven G., Allen, Isabel Elaine, Martin, Jeffrey N., Ndhlovu, Lishomwa C., Miller, Bruce L., Stephens, Melanie L., Hellmuth, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862406/
https://www.ncbi.nlm.nih.gov/pubmed/35043593
http://dx.doi.org/10.1002/acn3.51498
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author Apple, Alexandra C.
Oddi, Alexis
Peluso, Michael J.
Asken, Breton M.
Henrich, Timothy J.
Kelly, J. Daniel
Pleasure, Samuel J.
Deeks, Steven G.
Allen, Isabel Elaine
Martin, Jeffrey N.
Ndhlovu, Lishomwa C.
Miller, Bruce L.
Stephens, Melanie L.
Hellmuth, Joanna
author_facet Apple, Alexandra C.
Oddi, Alexis
Peluso, Michael J.
Asken, Breton M.
Henrich, Timothy J.
Kelly, J. Daniel
Pleasure, Samuel J.
Deeks, Steven G.
Allen, Isabel Elaine
Martin, Jeffrey N.
Ndhlovu, Lishomwa C.
Miller, Bruce L.
Stephens, Melanie L.
Hellmuth, Joanna
author_sort Apple, Alexandra C.
collection PubMed
description Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis.
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spelling pubmed-88624062022-02-27 Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19 Apple, Alexandra C. Oddi, Alexis Peluso, Michael J. Asken, Breton M. Henrich, Timothy J. Kelly, J. Daniel Pleasure, Samuel J. Deeks, Steven G. Allen, Isabel Elaine Martin, Jeffrey N. Ndhlovu, Lishomwa C. Miller, Bruce L. Stephens, Melanie L. Hellmuth, Joanna Ann Clin Transl Neurol Brief Communications Cognitive post‐acute sequelae of SARS‐CoV‐2 (PASC) can occur after mild COVID‐19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS‐CoV‐2 infection through structured interviews, neuropsychological testing, and optional cerebrospinal fluid (CSF) evaluations (53%). Delayed onset of cognitive PASC occurred in 43% and associated with younger age. Cognitive PASC participants had a higher number of pre‐existing cognitive risk factors (2.5 vs. 0; p = 0.03) and higher proportion with abnormal CSF findings (77% vs. 0%; p = 0.01) versus controls. Cognitive risk factors and immunologic mechanisms may contribute to cognitive PASC pathogenesis. Blackwell Publishing Ltd 2022-01-19 /pmc/articles/PMC8862406/ /pubmed/35043593 http://dx.doi.org/10.1002/acn3.51498 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Apple, Alexandra C.
Oddi, Alexis
Peluso, Michael J.
Asken, Breton M.
Henrich, Timothy J.
Kelly, J. Daniel
Pleasure, Samuel J.
Deeks, Steven G.
Allen, Isabel Elaine
Martin, Jeffrey N.
Ndhlovu, Lishomwa C.
Miller, Bruce L.
Stephens, Melanie L.
Hellmuth, Joanna
Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title_full Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title_fullStr Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title_full_unstemmed Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title_short Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID‐19
title_sort risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild covid‐19
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862406/
https://www.ncbi.nlm.nih.gov/pubmed/35043593
http://dx.doi.org/10.1002/acn3.51498
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