High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020

The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence in...

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Autores principales: Johansen, Malan, Svenstrup, Kirsten, Joensen, Poul, Steig, Bjarni á, Andorsdóttir, Guðrið, Hansen, Torben, Petersen, Maria Skaalum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862418/
https://www.ncbi.nlm.nih.gov/pubmed/35048555
http://dx.doi.org/10.1002/acn3.51501
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author Johansen, Malan
Svenstrup, Kirsten
Joensen, Poul
Steig, Bjarni á
Andorsdóttir, Guðrið
Hansen, Torben
Petersen, Maria Skaalum
author_facet Johansen, Malan
Svenstrup, Kirsten
Joensen, Poul
Steig, Bjarni á
Andorsdóttir, Guðrið
Hansen, Torben
Petersen, Maria Skaalum
author_sort Johansen, Malan
collection PubMed
description The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence interval [CI], 3.3–7.0) and the age‐ and sex‐standardized incidence (US 2010 Census Population) was 4.1/100,000 person‐years (95% CI, 2.7–6.0), which is a 68% increase from the 1987–2009 estimate. The 2020 crude prevalence was 9.5/100,000 (95% CI, 3.0–19.6) in a population of 52,912 inhabitants. Incidence and prevalence estimates of ALS in the Faroes are high and further research is warranted to uncover the genetic or environmental determinants of ALS in this population.
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spelling pubmed-88624182022-02-27 High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020 Johansen, Malan Svenstrup, Kirsten Joensen, Poul Steig, Bjarni á Andorsdóttir, Guðrið Hansen, Torben Petersen, Maria Skaalum Ann Clin Transl Neurol Brief Communications The Faroese population isolate harbors epidemiological and genetic characteristics that likely differ from outbred populations. This population‐based register study found that the Faroese 2010–2020 crude incidence of amyotrophic lateral sclerosis (ALS) was 4.9/100,000 person‐years (95% confidence interval [CI], 3.3–7.0) and the age‐ and sex‐standardized incidence (US 2010 Census Population) was 4.1/100,000 person‐years (95% CI, 2.7–6.0), which is a 68% increase from the 1987–2009 estimate. The 2020 crude prevalence was 9.5/100,000 (95% CI, 3.0–19.6) in a population of 52,912 inhabitants. Incidence and prevalence estimates of ALS in the Faroes are high and further research is warranted to uncover the genetic or environmental determinants of ALS in this population. Blackwell Publishing Ltd 2022-01-20 /pmc/articles/PMC8862418/ /pubmed/35048555 http://dx.doi.org/10.1002/acn3.51501 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Johansen, Malan
Svenstrup, Kirsten
Joensen, Poul
Steig, Bjarni á
Andorsdóttir, Guðrið
Hansen, Torben
Petersen, Maria Skaalum
High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title_full High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title_fullStr High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title_full_unstemmed High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title_short High incidence of amyotrophic lateral sclerosis in the Faroe Islands 2010–2020
title_sort high incidence of amyotrophic lateral sclerosis in the faroe islands 2010–2020
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862418/
https://www.ncbi.nlm.nih.gov/pubmed/35048555
http://dx.doi.org/10.1002/acn3.51501
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