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sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy

OBJECTIVE: Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic patients with neurovascular pathology compared with asymptomatic...

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Autores principales: da Silva‐Candal, Andrés, Custodia, Antia, López‐Dequidt, Iria, Rodríguez‐Yáñez, Manuel, Alonso‐Alonso, Maria Luz, Ávila‐Gómez, Paulo, Pumar, José M., Castillo, José, Sobrino, Tomás, Campos, Francisco, Iglesias‐Rey, Ramón, Hervella, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862435/
https://www.ncbi.nlm.nih.gov/pubmed/35060359
http://dx.doi.org/10.1002/acn3.51502
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author da Silva‐Candal, Andrés
Custodia, Antia
López‐Dequidt, Iria
Rodríguez‐Yáñez, Manuel
Alonso‐Alonso, Maria Luz
Ávila‐Gómez, Paulo
Pumar, José M.
Castillo, José
Sobrino, Tomás
Campos, Francisco
Iglesias‐Rey, Ramón
Hervella, Pablo
author_facet da Silva‐Candal, Andrés
Custodia, Antia
López‐Dequidt, Iria
Rodríguez‐Yáñez, Manuel
Alonso‐Alonso, Maria Luz
Ávila‐Gómez, Paulo
Pumar, José M.
Castillo, José
Sobrino, Tomás
Campos, Francisco
Iglesias‐Rey, Ramón
Hervella, Pablo
author_sort da Silva‐Candal, Andrés
collection PubMed
description OBJECTIVE: Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic patients with neurovascular pathology compared with asymptomatic subjects, and its association with circulating serum levels of soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK). METHODS: An observational study was conducted in which two groups of patients were compared. Group I (N = 242) comprised of asymptomatic subjects with arterial hypertension and/or diabetes or with a history of transient ischemic attacks, and Group II (N = 382) comprised patients with lacunar stroke or deep hemispheric intracerebral hemorrhage (ICH) of hypertensive origin. Serum levels of sTWEAK were analyzed and correlated with prevalence and intensity of LA according to the Fazekas scale. RESULTS: The prevalence of LA was higher in symptomatic (85.1%) versus asymptomatic patients (62.0%). Logistic regression model showed a significant relation of LA with neurovascular pathologies (OR: 2.69, IC 95%: 1.10–6.59, p = 0.003). When stratified according to the Fazekas scale, LA of grade II (OR: 3.53, IC 95%: 1.10–6.59, p = 0.003) and specially grade III (OR: 4.66, 95% CI: 1.09–19.84, p = 0.037) showed correlation with neurovascular pathologies. Increased sTWEAK levels were found in the symptomatic group in all LA grades (p < 0.0001), and associated with 5.06 times more risk of presenting clinical symptoms (OR: 5.06, 95% CI: 2.66–9.75, p < 0.0001). INTERPRETATION: LA showed a higher prevalence in patients with symptomatic lacunar stroke or deep hemispheric ICH. There is an association between sTWEAK levels and LA degree.
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spelling pubmed-88624352022-02-27 sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy da Silva‐Candal, Andrés Custodia, Antia López‐Dequidt, Iria Rodríguez‐Yáñez, Manuel Alonso‐Alonso, Maria Luz Ávila‐Gómez, Paulo Pumar, José M. Castillo, José Sobrino, Tomás Campos, Francisco Iglesias‐Rey, Ramón Hervella, Pablo Ann Clin Transl Neurol Research Articles OBJECTIVE: Leukoaraiosis (LA) refers to white matter lesions of undetermined etiology associated with the appearance and worsening of vascular pathologies. The aim is to confirm an increased frequency and intensity of LA in symptomatic patients with neurovascular pathology compared with asymptomatic subjects, and its association with circulating serum levels of soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK). METHODS: An observational study was conducted in which two groups of patients were compared. Group I (N = 242) comprised of asymptomatic subjects with arterial hypertension and/or diabetes or with a history of transient ischemic attacks, and Group II (N = 382) comprised patients with lacunar stroke or deep hemispheric intracerebral hemorrhage (ICH) of hypertensive origin. Serum levels of sTWEAK were analyzed and correlated with prevalence and intensity of LA according to the Fazekas scale. RESULTS: The prevalence of LA was higher in symptomatic (85.1%) versus asymptomatic patients (62.0%). Logistic regression model showed a significant relation of LA with neurovascular pathologies (OR: 2.69, IC 95%: 1.10–6.59, p = 0.003). When stratified according to the Fazekas scale, LA of grade II (OR: 3.53, IC 95%: 1.10–6.59, p = 0.003) and specially grade III (OR: 4.66, 95% CI: 1.09–19.84, p = 0.037) showed correlation with neurovascular pathologies. Increased sTWEAK levels were found in the symptomatic group in all LA grades (p < 0.0001), and associated with 5.06 times more risk of presenting clinical symptoms (OR: 5.06, 95% CI: 2.66–9.75, p < 0.0001). INTERPRETATION: LA showed a higher prevalence in patients with symptomatic lacunar stroke or deep hemispheric ICH. There is an association between sTWEAK levels and LA degree. Blackwell Publishing Ltd 2022-01-21 /pmc/articles/PMC8862435/ /pubmed/35060359 http://dx.doi.org/10.1002/acn3.51502 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
da Silva‐Candal, Andrés
Custodia, Antia
López‐Dequidt, Iria
Rodríguez‐Yáñez, Manuel
Alonso‐Alonso, Maria Luz
Ávila‐Gómez, Paulo
Pumar, José M.
Castillo, José
Sobrino, Tomás
Campos, Francisco
Iglesias‐Rey, Ramón
Hervella, Pablo
sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title_full sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title_fullStr sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title_full_unstemmed sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title_short sTWEAK is a leukoaraiosis biomarker associated with neurovascular angiopathy
title_sort stweak is a leukoaraiosis biomarker associated with neurovascular angiopathy
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862435/
https://www.ncbi.nlm.nih.gov/pubmed/35060359
http://dx.doi.org/10.1002/acn3.51502
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