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Neoantigen vaccine-induced CD4 T cells confer protective immunity in a mouse model of multiple myeloma through activation of CD8 T cells against non-vaccine, tumor-associated antigens

BACKGROUND: Cancer-associated neoantigens (neoAg) derived from tumor genomic sequencing and predictive algorithms for mutated peptides are a promising basis for therapeutic vaccines under investigation. Although these are generally designed to bind major histocompatibility complex class I and induce...

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Detalles Bibliográficos
Autores principales:	Bekri, Selma, Rodney-Sandy, Reunet, Gruenstein, Diana, Mei, Anna, Bogen, Bjarne, Castle, John, Levey, Daniel, Cho, Hearn Jay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862454/ https://www.ncbi.nlm.nih.gov/pubmed/35190376 http://dx.doi.org/10.1136/jitc-2021-003572

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