circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterized by clusters of cancer cells surrounded by a dense desmoplastic stroma. However, little is known about stromal cell heterogeneity in the pancreatic tumor microenvironment. METHODS: We conducted circRNA profiling in primary fibroblas...

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Detalles Bibliográficos
Autores principales: Zheng, Shangyou, Hu, Chonghui, Lin, Hongcao, Li, Guolin, Xia, Renpeng, Zhang, Xiang, Su, Dan, Li, Zhihua, Zhou, Quanbo, Chen, Rufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8862589/
https://www.ncbi.nlm.nih.gov/pubmed/35189958
http://dx.doi.org/10.1186/s13046-021-02237-6

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