A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

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We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcriptional regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (Δ3678). The Δ3678 virus replicates about 7,500-fold lower than wild-type SARS-CoV-2 on primary human airway cultures, b...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Zhang, Xianwen, Liu, Jianying, Xia, Hongjie, Zou, Jing, Muruato, Antonio E., Periasamy, Sivakumar, Plante, Jessica A., Bopp, Nathen E., Kurhade, Chaitanya, Bukreyev, Alexander, Ren, Ping, Wang, Tian, Menachery, Vineet D., Plante, Kenneth S., Xie, Xuping, Weaver, Scott C., Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863145/
https://www.ncbi.nlm.nih.gov/pubmed/35194609
http://dx.doi.org/10.1101/2022.02.14.480460
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