Ribosomal DNA promoter recognition is determined in vivo by cooperation between UBTF1 and SL1 and is compromised in the UBTF-E210K neuroregression syndrome

Transcription of the ~200 mouse and human ribosomal RNA genes (rDNA) by RNA Polymerase I (RPI/PolR1) accounts for 80% of total cellular RNA, around 35% of all nuclear RNA synthesis, and determines the cytoplasmic ribosome complement. It is therefore a major factor controlling cell growth and its mis...

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Detalles Bibliográficos
Autores principales: Tremblay, Michel G., Sibai, Dany S., Valère, Melissa, Mars, Jean-Clément, Lessard, Frédéric, Hori, Roderick T., Khan, Mohammad Moshahid, Stefanovsky, Victor Y., LeDoux, Mark S., Moss, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863233/
https://www.ncbi.nlm.nih.gov/pubmed/35139074
http://dx.doi.org/10.1371/journal.pgen.1009644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863233/
https://www.ncbi.nlm.nih.gov/pubmed/35139074
http://dx.doi.org/10.1371/journal.pgen.1009644

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