Cargando…

Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial

INTRODUCTION: Post-traumatic stress disorder (PTSD) is characterized by changes in both brain activity and microstructural integrity. Cumulative evidence demonstrates that hyperbaric oxygen therapy (HBOT) induces neuroplasticity and case-series studies indicate its potentially positive effects on PT...

Descripción completa

Detalles Bibliográficos
Autores principales: Doenyas-Barak, Keren, Catalogna, Merav, Kutz, Ilan, Levi, Gabriela, Hadanny, Amir, Tal, Sigal, Daphna-Tekoha, Shir, Sasson, Efrat, Shechter, Yarden, Efrati, Shai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863239/
https://www.ncbi.nlm.nih.gov/pubmed/35192645
http://dx.doi.org/10.1371/journal.pone.0264161
_version_ 1784655195748171776
author Doenyas-Barak, Keren
Catalogna, Merav
Kutz, Ilan
Levi, Gabriela
Hadanny, Amir
Tal, Sigal
Daphna-Tekoha, Shir
Sasson, Efrat
Shechter, Yarden
Efrati, Shai
author_facet Doenyas-Barak, Keren
Catalogna, Merav
Kutz, Ilan
Levi, Gabriela
Hadanny, Amir
Tal, Sigal
Daphna-Tekoha, Shir
Sasson, Efrat
Shechter, Yarden
Efrati, Shai
author_sort Doenyas-Barak, Keren
collection PubMed
description INTRODUCTION: Post-traumatic stress disorder (PTSD) is characterized by changes in both brain activity and microstructural integrity. Cumulative evidence demonstrates that hyperbaric oxygen therapy (HBOT) induces neuroplasticity and case-series studies indicate its potentially positive effects on PTSD. The aim of the study was to evaluate HBOT’s effect in veterans with treatment resistant PTSD. METHODS: Veterans with treatment resistant PTSD were 1:1 randomized to HBOT or control groups. All other brain pathologies served as exclusion criteria. Outcome measures included clinician-administered PTSD scale-V (CAPS-V) questionnaires, brief symptom inventory (BSI), BECK depression inventory (BDI), brain microstructural integrity evaluated by MRI diffuse tensor imaging sequence (DTI), and brain function was evaluated by an n-back task using functional MRI (fMRI). The treatment group underwent sixty daily hyperbaric sessions. No interventions were performed in the control group. RESULTS: Thirty-five veterans were randomized to HBOT (N = 18) or control (n = 17) and 29 completed the protocol. Following HBOT, there was a significant improvement in CAPS-V scores and no change in the control (F = 30.57, P<0.0001, Net effect size = 1.64). Significant improvements were also demonstrated in BSI and BDI scores (F = 5.72, P = 0.024 Net effect size = 0.89, and F = 7.65, P = 0.01, Net effect size = 1.03). Improved brain activity was seen in fMRI in the left dorsolateral prefrontal, middle temporal gyri, both thalami, left hippocampus and left insula. The DTI showed significant increases in fractional anisotropy in the fronto-limbic white-matter, genu of the corpus callosum and fornix. CONCLUSIONS: HBOT improved symptoms, brain microstructure and functionality in veterans with treatment resistant PTSD.
format Online
Article
Text
id pubmed-8863239
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-88632392022-02-23 Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial Doenyas-Barak, Keren Catalogna, Merav Kutz, Ilan Levi, Gabriela Hadanny, Amir Tal, Sigal Daphna-Tekoha, Shir Sasson, Efrat Shechter, Yarden Efrati, Shai PLoS One Research Article INTRODUCTION: Post-traumatic stress disorder (PTSD) is characterized by changes in both brain activity and microstructural integrity. Cumulative evidence demonstrates that hyperbaric oxygen therapy (HBOT) induces neuroplasticity and case-series studies indicate its potentially positive effects on PTSD. The aim of the study was to evaluate HBOT’s effect in veterans with treatment resistant PTSD. METHODS: Veterans with treatment resistant PTSD were 1:1 randomized to HBOT or control groups. All other brain pathologies served as exclusion criteria. Outcome measures included clinician-administered PTSD scale-V (CAPS-V) questionnaires, brief symptom inventory (BSI), BECK depression inventory (BDI), brain microstructural integrity evaluated by MRI diffuse tensor imaging sequence (DTI), and brain function was evaluated by an n-back task using functional MRI (fMRI). The treatment group underwent sixty daily hyperbaric sessions. No interventions were performed in the control group. RESULTS: Thirty-five veterans were randomized to HBOT (N = 18) or control (n = 17) and 29 completed the protocol. Following HBOT, there was a significant improvement in CAPS-V scores and no change in the control (F = 30.57, P<0.0001, Net effect size = 1.64). Significant improvements were also demonstrated in BSI and BDI scores (F = 5.72, P = 0.024 Net effect size = 0.89, and F = 7.65, P = 0.01, Net effect size = 1.03). Improved brain activity was seen in fMRI in the left dorsolateral prefrontal, middle temporal gyri, both thalami, left hippocampus and left insula. The DTI showed significant increases in fractional anisotropy in the fronto-limbic white-matter, genu of the corpus callosum and fornix. CONCLUSIONS: HBOT improved symptoms, brain microstructure and functionality in veterans with treatment resistant PTSD. Public Library of Science 2022-02-22 /pmc/articles/PMC8863239/ /pubmed/35192645 http://dx.doi.org/10.1371/journal.pone.0264161 Text en © 2022 Doenyas-Barak et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Doenyas-Barak, Keren
Catalogna, Merav
Kutz, Ilan
Levi, Gabriela
Hadanny, Amir
Tal, Sigal
Daphna-Tekoha, Shir
Sasson, Efrat
Shechter, Yarden
Efrati, Shai
Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title_full Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title_fullStr Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title_full_unstemmed Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title_short Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial
title_sort hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: a prospective, randomized, controlled trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863239/
https://www.ncbi.nlm.nih.gov/pubmed/35192645
http://dx.doi.org/10.1371/journal.pone.0264161
work_keys_str_mv AT doenyasbarakkeren hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT catalognamerav hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT kutzilan hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT levigabriela hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT hadannyamir hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT talsigal hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT daphnatekohashir hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT sassonefrat hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT shechteryarden hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial
AT efratishai hyperbaricoxygentherapyimprovessymptomsbrainsmicrostructureandfunctionalityinveteranswithtreatmentresistantposttraumaticstressdisorderaprospectiverandomizedcontrolledtrial