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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection w...

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Detalles Bibliográficos
Autores principales: Wang, Zhao Ni, Yang, Xiang Sheng, Sun, Jing, Zhao, Jin Cun, Zhong, Nan Shan, Tang, Xiao Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863311/
https://www.ncbi.nlm.nih.gov/pubmed/35224468
http://dx.doi.org/10.1016/j.isci.2022.103967
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author Wang, Zhao Ni
Yang, Xiang Sheng
Sun, Jing
Zhao, Jin Cun
Zhong, Nan Shan
Tang, Xiao Xiao
author_facet Wang, Zhao Ni
Yang, Xiang Sheng
Sun, Jing
Zhao, Jin Cun
Zhong, Nan Shan
Tang, Xiao Xiao
author_sort Wang, Zhao Ni
collection PubMed
description The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.
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spelling pubmed-88633112022-02-23 Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses Wang, Zhao Ni Yang, Xiang Sheng Sun, Jing Zhao, Jin Cun Zhong, Nan Shan Tang, Xiao Xiao iScience Article The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies. Elsevier 2022-02-22 /pmc/articles/PMC8863311/ /pubmed/35224468 http://dx.doi.org/10.1016/j.isci.2022.103967 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Zhao Ni
Yang, Xiang Sheng
Sun, Jing
Zhao, Jin Cun
Zhong, Nan Shan
Tang, Xiao Xiao
Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title_full Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title_fullStr Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title_full_unstemmed Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title_short Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
title_sort multi-omics evaluation of sars-cov-2 infected mouse lungs reveals dynamics of host responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863311/
https://www.ncbi.nlm.nih.gov/pubmed/35224468
http://dx.doi.org/10.1016/j.isci.2022.103967
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