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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses
The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863311/ https://www.ncbi.nlm.nih.gov/pubmed/35224468 http://dx.doi.org/10.1016/j.isci.2022.103967 |
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author | Wang, Zhao Ni Yang, Xiang Sheng Sun, Jing Zhao, Jin Cun Zhong, Nan Shan Tang, Xiao Xiao |
author_facet | Wang, Zhao Ni Yang, Xiang Sheng Sun, Jing Zhao, Jin Cun Zhong, Nan Shan Tang, Xiao Xiao |
author_sort | Wang, Zhao Ni |
collection | PubMed |
description | The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies. |
format | Online Article Text |
id | pubmed-8863311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-88633112022-02-23 Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses Wang, Zhao Ni Yang, Xiang Sheng Sun, Jing Zhao, Jin Cun Zhong, Nan Shan Tang, Xiao Xiao iScience Article The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. This multiplex evaluation also revealed that many kinases of the CDK and MAPK family were interactive and served as functional hubs in mediating the signal transduction during SARS-CoV-2 infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies. Elsevier 2022-02-22 /pmc/articles/PMC8863311/ /pubmed/35224468 http://dx.doi.org/10.1016/j.isci.2022.103967 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Zhao Ni Yang, Xiang Sheng Sun, Jing Zhao, Jin Cun Zhong, Nan Shan Tang, Xiao Xiao Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title | Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title_full | Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title_fullStr | Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title_full_unstemmed | Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title_short | Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses |
title_sort | multi-omics evaluation of sars-cov-2 infected mouse lungs reveals dynamics of host responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863311/ https://www.ncbi.nlm.nih.gov/pubmed/35224468 http://dx.doi.org/10.1016/j.isci.2022.103967 |
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