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Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study

BACKGROUND: Long-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hospitalised due to COVID-19 and compare it with survivors hospitalised due to oth...

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Autores principales: Rivera-Izquierdo, Mario, Láinez-Ramos-Bossini, Antonio Jesús, de Alba, Inmaculada Guerrero-Fernández, Ortiz-González-Serna, Rocío, Serrano-Ortiz, Álvaro, Fernández-Martínez, Nicolás Francisco, Ruiz-Montero, Rafael, Cervilla, Jorge A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863509/
https://www.ncbi.nlm.nih.gov/pubmed/35193574
http://dx.doi.org/10.1186/s12916-022-02292-6
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author Rivera-Izquierdo, Mario
Láinez-Ramos-Bossini, Antonio Jesús
de Alba, Inmaculada Guerrero-Fernández
Ortiz-González-Serna, Rocío
Serrano-Ortiz, Álvaro
Fernández-Martínez, Nicolás Francisco
Ruiz-Montero, Rafael
Cervilla, Jorge A.
author_facet Rivera-Izquierdo, Mario
Láinez-Ramos-Bossini, Antonio Jesús
de Alba, Inmaculada Guerrero-Fernández
Ortiz-González-Serna, Rocío
Serrano-Ortiz, Álvaro
Fernández-Martínez, Nicolás Francisco
Ruiz-Montero, Rafael
Cervilla, Jorge A.
author_sort Rivera-Izquierdo, Mario
collection PubMed
description BACKGROUND: Long-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hospitalised due to COVID-19 and compare it with survivors hospitalised due to other causes. METHODS: Prospective cohort study, the Andalusian Cohort of Hospitalised patients for COVID-19 (ANCOHVID study), conducted in 4 hospitals and 29 primary care centres in Andalusia, Spain. The sample was composed of 906 adult patients; 453 patients hospitalised due to COVID-19 (exposed) and 453 hospitalised due to other causes (non-exposed) from March 1 to April 15, 2020, and discharged alive. The main outcomes were (1) the prevalence of SPS at 12 months after discharge and (2) the incidence of SPS after discharge. Outcome data at 12 months were compared between the exposed and non-exposed cohorts. Risk ratios were calculated, and bivariate analyses were performed. RESULTS: A total of 163 (36.1%) and 160 (35.3%) patients of the exposed and non-exposed cohorts, respectively, showed at least one SPS at 12 months after discharge. The SPS with higher prevalence in the subgroup of patients hospitalised due to COVID-19 12 months after discharge were persistent pharyngeal symptoms (p<0.001), neurological SPS (p=0.049), confusion or memory loss (p=0.043), thrombotic events (p=0.025) and anxiety (p=0.046). The incidence of SPS was higher for the exposed cohort regarding pharyngeal symptoms (risk ratio, 8.00; 95% CI, 1.85 to 36.12), confusion or memory loss (risk ratio, 3.50; 95% CI, 1.16 to 10.55) and anxiety symptoms (risk ratio, 2.36; 95% CI, 1.28 to 4.34). CONCLUSIONS: There was a similar frequency of long-term SPS after discharge at 12 months, regardless of the cause of admission (COVID-19 or other causes). Nevertheless, some symptoms that were found to be more associated with COVID-19, such as memory loss or anxiety, merit further investigation. These results should guide future follow-up of COVID-19 patients after hospital discharge. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02292-6.
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spelling pubmed-88635092022-02-23 Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study Rivera-Izquierdo, Mario Láinez-Ramos-Bossini, Antonio Jesús de Alba, Inmaculada Guerrero-Fernández Ortiz-González-Serna, Rocío Serrano-Ortiz, Álvaro Fernández-Martínez, Nicolás Francisco Ruiz-Montero, Rafael Cervilla, Jorge A. BMC Med Research Article BACKGROUND: Long-term-specific sequelae or persistent symptoms (SPS) after hospitalisation due to COVID-19 are not known. The aim of this study was to explore the presence of SPS 12 months after discharge in survivors hospitalised due to COVID-19 and compare it with survivors hospitalised due to other causes. METHODS: Prospective cohort study, the Andalusian Cohort of Hospitalised patients for COVID-19 (ANCOHVID study), conducted in 4 hospitals and 29 primary care centres in Andalusia, Spain. The sample was composed of 906 adult patients; 453 patients hospitalised due to COVID-19 (exposed) and 453 hospitalised due to other causes (non-exposed) from March 1 to April 15, 2020, and discharged alive. The main outcomes were (1) the prevalence of SPS at 12 months after discharge and (2) the incidence of SPS after discharge. Outcome data at 12 months were compared between the exposed and non-exposed cohorts. Risk ratios were calculated, and bivariate analyses were performed. RESULTS: A total of 163 (36.1%) and 160 (35.3%) patients of the exposed and non-exposed cohorts, respectively, showed at least one SPS at 12 months after discharge. The SPS with higher prevalence in the subgroup of patients hospitalised due to COVID-19 12 months after discharge were persistent pharyngeal symptoms (p<0.001), neurological SPS (p=0.049), confusion or memory loss (p=0.043), thrombotic events (p=0.025) and anxiety (p=0.046). The incidence of SPS was higher for the exposed cohort regarding pharyngeal symptoms (risk ratio, 8.00; 95% CI, 1.85 to 36.12), confusion or memory loss (risk ratio, 3.50; 95% CI, 1.16 to 10.55) and anxiety symptoms (risk ratio, 2.36; 95% CI, 1.28 to 4.34). CONCLUSIONS: There was a similar frequency of long-term SPS after discharge at 12 months, regardless of the cause of admission (COVID-19 or other causes). Nevertheless, some symptoms that were found to be more associated with COVID-19, such as memory loss or anxiety, merit further investigation. These results should guide future follow-up of COVID-19 patients after hospital discharge. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-022-02292-6. BioMed Central 2022-02-23 /pmc/articles/PMC8863509/ /pubmed/35193574 http://dx.doi.org/10.1186/s12916-022-02292-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Rivera-Izquierdo, Mario
Láinez-Ramos-Bossini, Antonio Jesús
de Alba, Inmaculada Guerrero-Fernández
Ortiz-González-Serna, Rocío
Serrano-Ortiz, Álvaro
Fernández-Martínez, Nicolás Francisco
Ruiz-Montero, Rafael
Cervilla, Jorge A.
Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title_full Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title_fullStr Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title_full_unstemmed Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title_short Long COVID 12 months after discharge: persistent symptoms in patients hospitalised due to COVID-19 and patients hospitalised due to other causes—a multicentre cohort study
title_sort long covid 12 months after discharge: persistent symptoms in patients hospitalised due to covid-19 and patients hospitalised due to other causes—a multicentre cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863509/
https://www.ncbi.nlm.nih.gov/pubmed/35193574
http://dx.doi.org/10.1186/s12916-022-02292-6
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