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Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas

Several studies demonstrated the diagnostic accuracy of hair glucocorticoid measurement in patients with overt Cushing syndrome, but few data are available for patients with adrenal incidentaloma (AI) and cortisol autonomy. The aim of our study was to assess whether measurement of 5 corticosteroid h...

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Autores principales: Puglisi, Soraya, Leporati, Marta, Amante, Eleonora, Parisi, Alice, Pia, Anna Rosa, Berchialla, Paola, Terzolo, Massimo, Vincenti, Marco, Reimondo, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863572/
https://www.ncbi.nlm.nih.gov/pubmed/35222288
http://dx.doi.org/10.3389/fendo.2022.833514
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author Puglisi, Soraya
Leporati, Marta
Amante, Eleonora
Parisi, Alice
Pia, Anna Rosa
Berchialla, Paola
Terzolo, Massimo
Vincenti, Marco
Reimondo, Giuseppe
author_facet Puglisi, Soraya
Leporati, Marta
Amante, Eleonora
Parisi, Alice
Pia, Anna Rosa
Berchialla, Paola
Terzolo, Massimo
Vincenti, Marco
Reimondo, Giuseppe
author_sort Puglisi, Soraya
collection PubMed
description Several studies demonstrated the diagnostic accuracy of hair glucocorticoid measurement in patients with overt Cushing syndrome, but few data are available for patients with adrenal incidentaloma (AI) and cortisol autonomy. The aim of our study was to assess whether measurement of 5 corticosteroid hormones with the ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method in the keratin matrix is useful to stratify patients with AI by the presence of autonomous cortisol secretion [ACS] (defined as serum cortisol after 1 mg dexamethasone suppression test (DST) > 138 nmol/l) or possible ACS [PACS] (defined as serum cortisol after 1 mg DST > 50 nmol/l but ≤138 nmol/l). We analysed data of 67 AI patients (32 with cortisol autonomy) and 81 healthy subjects. We did not find any significant statistical difference comparing hair cortisol, cortisone, and 20β-dihydrocortisol concentrations between healthy controls and AI patients, while 6β-hydroxycortisol and 11-deoxycortisol were undetectable. Moreover, no significant difference was found in hair cortisol, cortisone, and 20β-dihydrocortisol levels of AI patients with or without cortisol autonomy. Finally, we did not find any correlation in patients with AI between hormonal concentrations in the keratin matrix and serum, salivary, and urinary cortisol levels, or with body mass index. In conclusion, our findings suggest that hair glucocorticoid measurement is not suitable as a diagnostic test for cortisol autonomy (ACS and PACS).
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spelling pubmed-88635722022-02-24 Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas Puglisi, Soraya Leporati, Marta Amante, Eleonora Parisi, Alice Pia, Anna Rosa Berchialla, Paola Terzolo, Massimo Vincenti, Marco Reimondo, Giuseppe Front Endocrinol (Lausanne) Endocrinology Several studies demonstrated the diagnostic accuracy of hair glucocorticoid measurement in patients with overt Cushing syndrome, but few data are available for patients with adrenal incidentaloma (AI) and cortisol autonomy. The aim of our study was to assess whether measurement of 5 corticosteroid hormones with the ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method in the keratin matrix is useful to stratify patients with AI by the presence of autonomous cortisol secretion [ACS] (defined as serum cortisol after 1 mg dexamethasone suppression test (DST) > 138 nmol/l) or possible ACS [PACS] (defined as serum cortisol after 1 mg DST > 50 nmol/l but ≤138 nmol/l). We analysed data of 67 AI patients (32 with cortisol autonomy) and 81 healthy subjects. We did not find any significant statistical difference comparing hair cortisol, cortisone, and 20β-dihydrocortisol concentrations between healthy controls and AI patients, while 6β-hydroxycortisol and 11-deoxycortisol were undetectable. Moreover, no significant difference was found in hair cortisol, cortisone, and 20β-dihydrocortisol levels of AI patients with or without cortisol autonomy. Finally, we did not find any correlation in patients with AI between hormonal concentrations in the keratin matrix and serum, salivary, and urinary cortisol levels, or with body mass index. In conclusion, our findings suggest that hair glucocorticoid measurement is not suitable as a diagnostic test for cortisol autonomy (ACS and PACS). Frontiers Media S.A. 2022-02-08 /pmc/articles/PMC8863572/ /pubmed/35222288 http://dx.doi.org/10.3389/fendo.2022.833514 Text en Copyright © 2022 Puglisi, Leporati, Amante, Parisi, Pia, Berchialla, Terzolo, Vincenti and Reimondo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Puglisi, Soraya
Leporati, Marta
Amante, Eleonora
Parisi, Alice
Pia, Anna Rosa
Berchialla, Paola
Terzolo, Massimo
Vincenti, Marco
Reimondo, Giuseppe
Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title_full Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title_fullStr Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title_full_unstemmed Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title_short Limited Role of Hair Cortisol and Cortisone Measurement for Detecting Cortisol Autonomy in Patients With Adrenal Incidentalomas
title_sort limited role of hair cortisol and cortisone measurement for detecting cortisol autonomy in patients with adrenal incidentalomas
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8863572/
https://www.ncbi.nlm.nih.gov/pubmed/35222288
http://dx.doi.org/10.3389/fendo.2022.833514
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